402567-99-1

Basic information

• Product Name: 5-Thiazolecarboxylic acid, 4-(1-methylethyl)-2-[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]-, methyl ester
• CAS NO: 402567-99-1
• Molecular Formula: C21H22N2O4S2
• Molecular Weight: 430.549
• Mol File: 402567-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxylic acid, 4-(1-methylethyl)-2-[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxylic acid, 4-(1-methylethyl)-2-[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]-, methyl ester(402567-99-1)
• EPA Substance Registry System: 5-Thiazolecarboxylic acid, 4-(1-methylethyl)-2-[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]-, methyl ester(402567-99-1)

Safety Data

• Hazardous Substances Data: 402567-99-1(Hazardous Substances Data)

Upstream product

• 2454-39-9 2-aminobenzothioamide 
• 28144-70-9 anthranilic acid amide 
• 98-59-9 p-toluenesulfonyl chloride 
• 402567-97-9 2-(2-amino-phenyl)-4-isopropyl-thiazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Copper(I) bromide-mediated synthesis of novel 2-arylthiazole-5-carboxylates from α-diazo-β-keto esters and aromatic thioamides

Starting from readily available α-diazo-β-keto esters 8 and aromatic primary thioamides 9 and 14, a simple synthesis of 2-aryl 4-substituted thiazole-5-carboxylate derivatives of type 10 and 16 has been accomplished. The method is based on the efficient catalysis of CuBr, which promotes the formation of the corresponding carbenoids 11 from diazo derivatives 8. These Cu-carbenoids 11 react with the thiocarbonyl group of the primary thioamides to afford presumably intermediates of the general type 12, which by subsequent cyclocondensation furnish the title thiazole derivatives.