40257-02-1

Basic information

• Product Name: (3-nitrophenoxy)acetyl chloride
• Synonyms: (3-nitrophenoxy)acetyl chloride;2-(3-Nitrophenoxy)acetic acid chloride
• CAS NO: 40257-02-1
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.59054
• EINECS: 254-861-4
• Mol File: 40257-02-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.2°C at 760 mmHg
• Flash Point: 153.5°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: (3-nitrophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3-nitrophenoxy)acetyl chloride(40257-02-1)
• EPA Substance Registry System: (3-nitrophenoxy)acetyl chloride(40257-02-1)

Safety Data

• Hazardous Substances Data: 40257-02-1(Hazardous Substances Data)

Usage

General Description

(3-nitrophenoxy)acetyl chloride, also known as 3-nitrophenoxyacetyl chloride, is a chemical compound commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a colorless to pale yellow liquid with a strong, pungent odor. (3-nitrophenoxy)acetyl chloride is a reactive compound and is highly corrosive, posing significant risks to human health if not handled properly. It is widely used in industrial processes for the production of various chemicals and is also utilized in research and development activities. Due to its reactivity and potential hazards, appropriate safety measures and protective equipment must be used when handling this compound.

InChI:InChI=1/C8H6ClNO4/c9-8(11)5-14-7-3-1-2-6(4-7)10(12)13/h1-4H,5H2

Upstream product

• 1878-88-2 2-(3-nitrophenoxy)acetic acid 
• 5544-77-4 2-(3-nitrophenoxy)-acetic acid ethyl ester 
• 554-84-7 meta-nitrophenol 
• 3019-85-0 sodium 3-nitrophenoxide 

Downstream Products

• 81720-19-6 1-methoxycarbonylmethyloxy-3-nitrobenzene 
• 136776-23-3 2-(3-Nitro-phenoxy)-1-phenothiazin-10-yl-ethanone 
• 134145-71-4 1-Carbazol-9-yl-2-(3-nitro-phenoxy)-ethanone 
• 205694-08-2 cyclopentyl 2-(3-nitrophenoxy)acetate 
• 205694-07-1 isopropyl 2-(3-nitrophenoxy)acetate 
• 90370-49-3 (3-nitrophenoxy)acetamide 
• 184944-87-4 N-(2-(3-aminophenoxy)acetyl)morpholine 
• 50508-38-8 4-[(3-nitro-phenoxy)-acetyl]-morpholine 
• 205694-32-2 cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate 
• 205694-31-1 cyclopentyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate 
• 205694-30-0 isopropyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate 
• 205694-38-8 cyclohexyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate 
• 205694-37-7 cyclopentyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate 
• 205694-36-6 isopropyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate 

Relevant articles and documents

ADHESIVE FORMULATIONS

The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a polymeric polyol core, which may be treated with a nitroaryl compound to form a nitro ester. The resulting nitro ester groups may be reduced to form amino groups which, in turn, may be treated to form isocyanate groups. The resulting isocyanate may then be reacted with a second component to form adhesive and/or sealant compositions.

A convenient preparation of N-alkyl and N-arylamines by smiles rearrangement - Synthesis of analogues of diclofenac

Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.

Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors

A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that N-methyl-N-phenyl-2-[2-[N-(N-methyl-N- phenyl-carbamoylmethyl)-N-[2-[3-(3- methylphenyl)ureido]acetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.