4028-63-1 Usage
Uses
Different sources of media describe the Uses of 4028-63-1 differently. You can refer to the following data:
1. suzuki reaction
2. Iodomesitylene can be used as a good catalyst for living radical polymerization due to its good molecular weight distribution.
Hazard
May cause eye, skin, and respiratory tract irritation. Light sensitive.
Health effects
Eye: May cause eye irritation.Skin: May cause skin irritation. May be harmful if absorbed through the skin.Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be?harmful if inhaled.
Synthesis
The synthesis of?2,4,6-Trimethyliodobenzene is as follows:A 10 mL glass flask equipped with a magnetic stir bar wascharged with a methyl ketone (1 mmol) and dissolved in MeCN (2 mL). To thermostat solution NH4NO3 (10-25 mol%), I2 (50 mol%) and H2SO4 (aqueous 96% solution, 10-20 mol%) were added and the flask was furtherequipped with a balloon filled with air (1 L) and magnetically stirred at 60 C.The consumption of starting material was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature, diluted withEtOAc (10 mL), and insoluble material identified as ammonium sulfate filtered off. The filtrate neutralized with NaHCO3 (aqueous 10% solution, 2 mL)and Na2S2O3 (aqueous 10% solution, 2 mL) and phase was separated. The waterphase was washed with EtOAc additionally two times (2 5 mL). The combined organic phase was dried over anhydrous Na2SO4 and the solvent distilled under reduced pressure. The crude product obtained was analyzed by 1H NMR. Finally, the crude product was purified using column chromatography (SiO2, n-hexane/CH2Cl2 elution) and preparative thin layer chromatography to afford purematerial.
storage
Store in a cool, dry place. Store in a tightly closed container. Store protected from light.
Check Digit Verification of cas no
The CAS Registry Mumber 4028-63-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4028-63:
(6*4)+(5*0)+(4*2)+(3*8)+(2*6)+(1*3)=71
71 % 10 = 1
So 4028-63-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H11I/c1-6-4-7(2)9(10)8(3)5-6/h4-5H,1-3H3
4028-63-1Relevant articles and documents
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Rosenberg
, p. 4389 (1954)
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NCBSI/KI: A Reagent System for Iodination of Aromatics through in Situ Generation of I-Cl
Palav, Amey,Misal, Balu,Chaturbhuj, Ganesh
, p. 12467 - 12474 (2021/08/24)
In situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system has been developed. The NCBSI reagent requires no activation due to longer bond length, lower bond dissociation energy, and higher absolute charge density on nitrogen. The system is adequate for mono- and diiodination of a wide range of moderate to highly activated arenes with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide can be recovered and transformed to NCBSI, making the protocol eco-friendly and cost-effective.
Pseudocyclic bis-N-heterocycle-stabilized iodanes - synthesis, characterization and applications
Boelke, Andreas,Lork, Enno,Nachtsheim, Boris J.,Sadat, Soleicha
supporting information, p. 7434 - 7437 (2021/08/03)
Bis-N-heterocycle-stabilized λ3-iodanes (BNHIs) based on azoles are introduced as novel structural motifs in hypervalent iodine chemistry. A performance test in a variety of benchmark reactions including sulfoxidations and phenol dearomatizations revealed a bis-N-bound pyrazole substituted BNHI as the most reactive derivative. Its solid-state structure was characterizedviaX-ray analysis implying strong intramolecular interactions between the pyrazole nitrogen atoms and the hypervalent iodine centre.
