40283-41-8

Usage

Uses

Used in Pharmaceutical Research:
2-Aminothiazole-4-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceutical drugs and organic compounds. Its presence in the molecular structure of these compounds can influence their pharmacological properties, making it an essential component in drug discovery and development.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Aminothiazole-4-carboxylic acid serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and functional groups allow for various chemical reactions, facilitating the synthesis of complex molecules with specific properties.
Used in Antimicrobial Applications:
2-Aminothiazole-4-carboxylic acid has been studied for its antimicrobial properties, making it a potential candidate for the development of new antimicrobial agents. Its ability to inhibit the growth of bacteria and other microorganisms can contribute to the fight against antibiotic-resistant strains and the development of novel treatments for infectious diseases.
Used in Antifungal Applications:
Similarly, 2-Aminothiazole-4-carboxylic acid has demonstrated antifungal properties, which can be harnessed in the development of antifungal drugs. Its potential to combat fungal infections can be beneficial in treating various fungal diseases and addressing the need for new antifungal therapies.

InChI:InChI=1/C4H4N2O2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H2,5,6)(H,7,8)/p-1

Upstream product

• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 5398-36-7 2-aminothiazole-4-carboxylate 

Downstream Products

• 5198-87-8 2-chlorothiazole-4-carboxylic acid 
• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 858486-46-1 2-amino-5-bromo-1,3-thiazole-4-carboxylic acid 

Relevant academic research and scientific papers

ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS

The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.

Novel FLT3 kinase inhibitor and application thereof

The invention provides a novel FLT3 kinase inhibitor. The novel FLT3 kinase inhibitor comprises a compound shown in the formula (I) or pharmacy acceptable salt or solvate or isomer or ester or acid or metabolin or prodrug. The invention also provides a pharmaceutical composition of the compound shown in the formula (I) and an application and method of the pharmaceutical composition for preventing or treating cell proliferation disease and/or FLT3 and c-Kit related disease and disease responding to FLT3 kinase ( particularly, responding to FLT3/ITD mutant kinase) inhibition.

C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS

Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3

The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.

AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT

An amide derivative represented by the following Formula (1) is provided as an amide derivative showing a significantly excellent effect for a pest control action. In the following Formula (1), A represents a carbon atom, a nitrogen atom, or the like, and K represents a non-metal atomic group necessary for forming a cyclic linking group derived from benzene or a heterocyclie. X represents a halogen atom or the like; n represents an integer of from 0 to 4. R1 and R2 represent hydrogen atoms, alkyl groups, or the like. T represents -C(=G1)-Q1 or -C(=G1)-G2Q2, and G1 to G3 each represent oxygen atoms or the like. Q1 and Q2 each represent a hydrogen atom, an alkyl group, an aryl group, or the like. Y1 and Y5 each represent a halogen atom or the like, Y2 and Y4 each represent a hydrogen atom or the like, and Y3 represents a C2-C5 haloalkyl group.

AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD

A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents -C(=G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.