402846-45-1Relevant academic research and scientific papers
Diexo-3-aminonorbornane-2-carboxylic acid as highly applicable chiral, source for the enantioselective synthesis of heterocycles
Fül?p, Ferenc,Miklós, Ferenc,Forróa, Eniko
, p. 1687 - 1689 (2008)
Diastereomers of tetracyclic pyrrolopyrimidine derivatives 2 and 3 were prepared in a three-step domino reaction from diexo-3-aminobicyclo[2.2.1]hept-5- ene-2-carboxamide with levulinic acid or p-toluoylpropionic acid. When subjected to a microwave-mediated retro-Diels-Alder reaction, these tetracycles furnished bicyclic pyrrolo[1,2-a]pyrimidines through the loss of cyclopentadiene. When enantiomeric diexo-3-aminobicyclo 2.2.1]hept-5-ene-2-carboxamide was used, the products were enantiomeric heterocycles with ee >99%, demonstrating that the title compound is an excellent chiral source. Thieme Stuttgart.
Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers
Miklós, Ferenc,Bozó, Kristóf,Galla, Zsolt,Haukka, Matti,Fül?p, Ferenc
, p. 1401 - 1406 (2017/10/06)
The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(?)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(?)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (?)-9b, (?)-10b and (?)-10c.
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity
Ott, Gregory R.,Tripathy, Rabindranath,Cheng, Mangeng,McHugh, Robert,Anzalone, Andrew V.,Underiner, Ted L.,Curry, Matthew A.,Quail, Matthew R.,Lu, Lihui,Wan, Weihua,Angeles, Thelma S.,Albom, Mark S.,Aimone, Lisa D.,Ator, Mark A.,Ruggeri, Bruce A.,Dorsey, Bruce D.
scheme or table, p. 493 - 498 (2011/03/19)
A series of novel 7-amino-1,3,4,5-tetrahydrobenzo[b]azepin-2-one derivatives within the diaminopyrimidine class of kinase inhibitors were identified that target anaplastic lymphoma kinase (ALK). These inhibitors are potent against ALK in an isolated enzym
Stereochemical Studies, 106. - Saturated Heterocycles, 110. - Synthesis of Methylene-bridged Partially Saturated Quinazolones
Stajer, Geza,Szabo, Angela E.,Fueloep, Ferenc,Bernath, Gabor,Sohar, Pal
, p. 259 - 264 (2007/10/02)
With imidates, esters (5-8) of di-endo (1 and 2) and di-exo (3 and 4) norbornane- and norbornene-β-amino acids yield methylene-bridged tetrahydro- (18 and 20) and hexahydro-4-quinazolinones (17 and 19); the reaction of the corresponding carboxamides (9-12
