402913-49-9Relevant academic research and scientific papers
Enantioselective synthesis of pantolactone analogues from an ephedrine-derived morpholine-dione
Pansare, Sunil V.,Bhattacharyya, Annyt
, p. 3275 - 3282 (2007/10/03)
An efficient enantioselective synthesis of β,β-dialkyl α-hydroxy γ-butyrolactones, analogues of pantolactone, has been developed employing a stereoselective Prins reaction of chiral alkylidene morpholinones, as the key step. Enantioselective synthesis of a naturally occurring pantolactone homologue and a spiro analogue of pantolactone was achieved with this protocol.
Enantioselective synthesis of β,β-dialkyl α-hydroxy γ-butyrolactones
Pansare, Sunil V.,Bhattacharyya, Annyt
, p. 9265 - 9267 (2007/10/03)
An ephedrine-derived morpholine dione is employed in the synthesis of chiral alkylidene morpholinones that are efficiently converted to β-substituted α,γ-dihydroxy butyramides, precursors of the corresponding butyrolactones. Enantioselective synthesis of a spiro analog of pantolactone as well as a naturally occurring pantolactone homolog is achieved with this protocol.
