402925-42-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 402925-41-1 (4S,1'R,1''S)-4-[3'-(1''-methoxycarbonyl-2''-phenyl-ethylamino)-1'-methylpropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 515173-87-2 (1'R,4S)-4-(3'-hydroxy-1'-methyl-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 402925-40-0 (4S,1'R)-2,2-dimethyl-4-(1'-methyl-3'-oxopropyl)oxazolidine-3-carboxylic acid tert-butyl ester 
• 134525-18-1 (2E',4S)-4-(2'-ethoxycarbonyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 131713-28-5 (1'R,4S)-4-(2'-ethoxycarbonyl-1'-methyl-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 862473-12-9 pentafluorophenyl (2S,3R,1'S)-5-[benzyloxycarbonyl-(1'-methoxycarbonyl-2'-phenylethyl)amino]-2-tert-butoxycarbonylamino-3-methyl-pentanoate 
• 402925-43-3 (2S,3R,1'S)-5-[benzyloxycarbonyl-(1'-methoxycarbonyl-2'-phenylethyl)amino]-2-tert-butoxycarbonylamino-3-methyl-pentanoic acid 

Relevant academic research and scientific papers

Synthesis of 4-substituted-3-aminopiperidin-2-ones: Application to the synthesis of a conformationally constrained tetrapeptide N-acetyl-Ser-Asp-Lys- Pro

A new and practical synthetic strategy is developed for the synthesis of six-membered lactam-bridged dipeptides, 4-substituted-3-aminopiperidin-2-ones, featuring two key steps: (a) a diastereoselective addition of cuprate to (E)-α,β-unsaturated ester (3)

A novel approach for the asymmetric synthesis of (3S,4R)-3-amino-4-alkyl-2-piperidinones: Conformationally constrained dipeptides

A straightforward method is developed for the synthesis of enantiopure (3S,4R)-3-amino-4-alkyl-2-piperidinone derivatives, six-membered lactam-bridged dipeptides, via highly diastereofacial selective 1,4-addition of organocuprate to the chiral oxazolidine