402929-57-1Relevant academic research and scientific papers
2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents
Emami, Saeed,Foroumadi, Alireza,Falahati, Mehraban,Lotfali, Ensieh,Rajabalian, Saeed,Ebrahimi, Soltan-Ahmed,Farahyar, Shirin,Shafiee, Abbas
, p. 141 - 146 (2008/09/17)
2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 μg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.
Stereoselective syntheses of (E)- and (Z)-2,3-dihydro-3-(1,2,4-triazolyl)-4H-1-benzopyran-4-one oxime ethers
Emami, Saeed,Shafiee, Abbas
, p. 2059 - 2074 (2007/10/03)
A synthesis of (E)-and (Z) -2,3-dihydro-3-(1H-1,2,4-triazol-1-y1)-4H-1-benzopyran-4-one oxime ethers [(E)- and (Z)-13] and (Z)-2,3-dihydro-3-(4H-1,2,4-triazol-4-y1)-4H-1-benzopyran-4-one oxime ethers [(Z)-17] are described. Ring closure of 2-(1,2,4-triazolyl)-2′-hydroxy-acetophenones (5 or 6) followed by reaction with HONH2.HCl gave the corresponding (Z)-oximes [(Z)-11 or (Z)-16]. O-Alkylation of (Z)- oximes afforded (Z)-oxime ethers [(Z)-13 or (Z)-17]. Reaction of (Z)-3-bromo-2,3-dihydro-4H-1-benzopyran-4-one oxime (18) with 1,2,4-triazole afforded (E)-oxime [(E)-11]. O-Alkylation of (E)-oxime gave the desired (E)-oxime ethers [(E)-I3]. In addition, (Z)-oxime ethers [(Z)-13 or (Z)-17)] could also be obtained from the reaction of 2.3-dihydro-3-(1,2,4-triazolyl)-4H-1-benzopyran-4-ones (2 or 14) with O-(arylmethyl)hydroxylamine hydrochloride (19).
