402929-57-1

Basic information

• Product Name: Ethanone, 1-(4-chloro-2-hydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)-
• CAS NO: 402929-57-1
• Molecular Formula: C10H8ClN3O2
• Molecular Weight: 237.645
• Mol File: 402929-57-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-chloro-2-hydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-chloro-2-hydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)-(402929-57-1)
• EPA Substance Registry System: Ethanone, 1-(4-chloro-2-hydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)-(402929-57-1)

Safety Data

• Hazardous Substances Data: 402929-57-1(Hazardous Substances Data)

Upstream product

• 288-88-0 1,2,4-Triazole 
• 157068-00-3 2-bromo-1-(4-chloro-2-hydroxyphenyl)ethan-1-one 

Relevant articles and documents

2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 μg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.