402932-84-7Relevant academic research and scientific papers
Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents
Liu, Xin-Hua,Liu, Hui-Feng,Chen, Jin,Yang, Yang,Song, Bao-An,Bai, Lin-Shan,Liu, Jing-Xin,Zhu, Hai-Liang,Qi, Xing-Bao
scheme or table, p. 5705 - 5708 (2010/11/17)
A series of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential telomerase inhibitors were synthesized. The bioassay tests show that compound 3d exhibited potentially high activity against human gastric cancer cell SGC-7901 with IC50 value of 2.69 ± 0.60 μg/mL. All title compounds were assayed for telomerase inhibition by a modified TRAP assay, the results show that compounds 3d and 3f can strongly inhibit telomerase with IC50 values of 2.0 ± 0.07 and 1.8 ± 0.35 μM, respectively. Docking simulation was performed to position compound 3d into the telomerase (3DU6) active site to determine the probable binding model.
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents
Khode, Suresh,Maddi, Veeresh,Aragade, Prashant,Palkar, Mahesh,Ronad, Pradeep Kumar,Mamledesai, Shivalingarao,Thippeswamy,Satyanarayana
experimental part, p. 1682 - 1688 (2009/06/20)
A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a-l) were synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl)propan-1-ones (2a-l) with phenylhydrazine in the presence of hot pyridine. Structures of all new s
