402944-81-4

Basic information

• Product Name: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID
• Synonyms: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID;3-(1H-Benzimidazol-2-yl)benzoic acid;3-(1H-benzo[d]iMidazol-2-yl)benzoic acid;2-(3-Carboxyphenyl)-1H-benzimidazole
• CAS NO: 402944-81-4
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.24
• Product Categories: Benzimidazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis
• Mol File: 402944-81-4.mol

Chemical Properties

• Boiling Point: 530.4 °C at 760 mmHg
• Flash Point: 274.6 °C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 4.44E-12mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(402944-81-4)
• EPA Substance Registry System: 3-(1H-BENZOIMIDAZOL-2-YL)-BENZOIC ACID(402944-81-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 402944-81-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3-(1H-Benzoimidazol-2-yl)-Benzoic Acid is utilized as a research compound for its potential therapeutic properties. It is particularly noted for its anti-inflammatory and anti-cancer activities, which make it a promising candidate for the development of new drugs targeting these conditions.
Used in the Synthesis of Biologically Active Compounds:
In the field of organic chemistry, 3-(1H-Benzoimidazol-2-yl)-Benzoic Acid serves as a key building block. Its structural components allow it to be incorporated into the synthesis of other biologically active compounds, thereby expanding the range of its applications in medicinal chemistry.
Used in Medicinal Chemistry:
3-(1H-Benzoimidazol-2-yl)-Benzoic Acid is employed as a versatile molecule in medicinal chemistry. Its unique combination of functional groups and structural features positions it as a candidate for the design and development of novel therapeutic agents, particularly those with anti-inflammatory and anti-cancer properties.

InChI:InChI=1/C14H10N2O2/c17-14(18)10-5-3-4-9(8-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,(H,15,16)(H,17,18)

Upstream product

• 619-21-6 m-formylphenyl benzoic acid 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 885463-19-4 2-(3-carboethoxyphenyl)benzimidazole 

Relevant articles and documents

Metal-organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway

Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH2-MIL-125(Ti) MOF surface through electron deficient Ti4+ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.

Novel compounds useful for bradykinin B1 receptor antagonism

Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.

Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury

A novel series of benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines were designed and synthesized as Na+/H+exchanger inhibitors. Most of them were found to inhibit NHE1-mediated platelet swelling in a concentration-dependent manner, and to have significant cardioprotective effect against myocardial ischemic-reperfusion injury, among which compounds 10a and 34 were more potent than cariporide in both in vivo and in vitro tests.