40299-87-4

Basic information

• Product Name: CHEMBRDG-BB 4023671
• Synonyms: CHEMBRDG-BB 4023671;4-(BROMOACETYL)MORPHOLINE;morpholine, 4-(bromoacetyl)-;4-(bromoacetyl)morpholine(SALTDATA: FREE);2-BroMo-1-(Morpholin-4-yl)ethanone;4-(2-BroMoacetyl)Morpholine;2-BroMo-1-(Morpholin-4-yl)ethan-1-one;2-Bromo-1-morpholinoethanone
• CAS NO: 40299-87-4
• Molecular Formula: C₆H₁₀BrNO₂
• Molecular Weight: 208.05
• Mol File: 40299-87-4.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 308.452 °C at 760 mmHg
• Flash Point: 140.347 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: CHEMBRDG-BB 4023671(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 4023671(40299-87-4)
• EPA Substance Registry System: CHEMBRDG-BB 4023671(40299-87-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 40299-87-4(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 4023671, also known as 5-aminolevulinic acid, is a chemical compound with the molecular formula C5H9NO3. It is a synthetic analogue of a natural compound that plays a crucial role in the biosynthesis of tetrapyrroles, such as heme, chlorophyll, and bilirubin. 5-aminolevulinic acid is used as a pharmaceutical intermediate and in the production of drugs for the treatment of photodynamic therapy. It is also used in the diagnosis and treatment of certain types of cancer, as well as in the management of bladder cancer and actinic keratosis. Additionally, it is used in the agricultural industry as a plant growth regulator and in the synthesis of herbicides and pesticides.

InChI:InChI=1/C6H10BrNO2/c7-5-6(9)8-1-3-10-4-2-8/h1-5H2

Upstream product

• 1696-20-4 4-acetylmorpholine 
• 110-91-8 morpholine 
• 79-08-3 bromoacetic acid 
• 13094-51-4 bromoacetic anhydride 
• 598-21-0 2-Bromoacetyl bromide 
• 22118-09-8 2-bromoacetyl chloride 

Downstream Products

• 352306-81-1 4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxy-ethyl)-1-methyl-2-[7-methylthio-6-(4-morpholine-carbonylmethyl)imidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate bromide 
• 252872-12-1 (3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-1-benzyl-3-((cyclopentyloxy)[3-(2-morpholino-2-oxoethoxy)phenyl]sulfonylamino)-2-hydroxypropyl]carbamate 
• 1554421-97-4 C₂₃H₃₁N₅O₈ 
• 1554422-09-1 C₂₀H₃₃N₉O₈ 
• 1554422-07-9 1-((1R,2S,3R,4R,5S)-5-azido-2-hydroxy-4-((1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-(2-morpholino-2-oxoethoxy)cyclohexyl)-3-(2-hydroxyethyl)urea 
• 1554421-94-1 (3aR,5S,6R,7S,7aS)-5-azido-6-hydroxy-3-(4-methoxy benzyl)-7-(2-morpholino-2-oxoethoxy)hexahydrobenzo[d]oxazol-2(3H)-one 
• 1360467-58-8 4-methylbenzenesulfinic acid 1,1,3,3-tetramethylguanidine salt 
• 1441749-58-1 5-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-4-(2-morpholin-4-yl-2-oxo-ethyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one 
• 1380491-23-5 2-azido-2-(2,5-dimethylphenyl)-1-morpholinoethanone 
• 1380491-15-5 2-azido-2-(2-methylphenyl)-1-morpholinoethanone 

Relevant articles and documents

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Low toxicity functionalised imidazolium salts for task specific ionic liquid electrolytes in dye-sensitised solar cells: A step towards less hazardous energy production

Novel solvent free task specific ionic liquid (TSIL) electrolytes for dye sensitised solar cells (DSSC) were synthesised and tested. Of great concern is the replacement of low-moderate toxicity second generation ILs, with high toxicity third generation TSILs. As most 1-butyl-3-methylimidazolium (Bmim) and especially 1-ethyl-3-methylimidazolium (Emim) based ILs have low toxicity, the designing of replacement TSILs of comparable toxicity is a challenge. Structural features of TSIL investigated herein were incorporation of heteroatoms into the side chain of imidazolium cations (i.e. ether, ester and amide) and anion (bromide, iodide, and triflimide [NTf2]). Preliminary toxicity screening against 20 microorganisms (8 bacteria and 12 fungi) found that all ILs, imidazolium salts, N-butylbenzimidazole (NBB) and guanidinium thiocyanate (GNCS) do not exhibit high antimicrobial toxicity. However NBB and a pentyl ester substituted IL displayed moderate toxicity to several strains of bacteria and fungi. Further toxicity testing to establish IC50 values shows several novel TSIL compounds and imidazolium salts are in fact less toxic to microorganisms (e.g. bacteria) than commonly used 1-ethyl-3-methylimidazolium iodide (EmimI) and 1,3-dimethylimidazolium iodide (DmimI). We have demonstrated that the presence of ether and either ester or amide groups in the structure of the cation of the TSIL and imidazolium salts reduces antimicrobial toxicity, which is consistent with the lowering of the lipophilicity of ILs. Iodide and bromide analogues have lower toxicity than the NTf2 examples in this study. The DSSC performance using these "greener" ILs in place of the standard EmimI compare quite favourably. Two low antibacterial toxicity iodide examples exhibit photocurrents of 9.27 mA cm-2 and 8.85 mA cm -2, respectively, achieving promising efficiencies of 3.39% and 3.31%, respectively (EmimI = 4.94%). DSSC performance is further improved by 15% minimum to 66% maximum, depending on IL chosen, by the presence of small amounts of moisture and DSSCs employing a low antibacterial toxicity iodide TSIL or imidazolium salt can surpass the performance of dry EmimI. Of note the DSSC containing TSIL NTf2 examples, performed poorly compared to the halide analogues, with the outcome that the most toxic TSILs under investigation are also the least preferred based on performance. the Partner Organisations 2014.

Benzofuran substituted amide compound as well as preparation method and application thereof

The invention relates to a benzofuran substituted amide compound as well as a preparation method and application thereof. The chemical structural general formula of the benzofuran substituted amide compound is represented by a formula VII. The invention discloses the structural general formula, a synthetic route and a preparation method of the benzofuran substituted amide compound, an application of the benzofuran substituted amide compound in a pesticide composition and an application of the benzofuran substituted amide compound in prevention and treatment of plant diseases in agriculture, forestry and horticulture when the benzofuran substituted amide compound is combined with a bactericide.

Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from Trypanosoma cruzi

Chagas disease is a parasitic infection affecting millions of people across Latin America, imposing a dramatic socioeconomic burden. Despite the availability of drugs, nifurtimox and benznidazole, lack of efficacy and incidence of side-effects prompt the identification of novel, efficient, and affordable drug candidates. To address this issue, one strategy could be probing the susceptibility of Trypanosoma parasites toward NADP-dependent enzyme inhibitors. Recently, steroids of the androstane group have been described as highly potent but nonselective inhibitors of parasitic glucose-6-phosphate dehydrogenase (G6PDH). In order to promote selectivity, we have synthesized and evaluated 26 steroid derivatives of epiandrosterone in enzymatic assays, whereby 17 compounds were shown to display moderate to high selectivity for T. cruzi over the human G6PDH. In addition, three compounds were effective in killing intracellular T. cruzi forms infecting rat cardiomyocytes. Altogether, this study provides new SAR data around G6PDH and further supports this target for treating Chagas disease.