40345-42-4Relevant academic research and scientific papers
(m.n)-Homorubins: Syntheses and structures
Pfeiffer, William P.,Lightner, David A.
, p. 1777 - 1801 (2015/02/19)
Five new homorubin analogs of bilirubin with their two dipyrrinone components conjoined to (CH2)2, (CH2)3, and (CH2)4 units were synthesized with propionic acid chains shortened to acetic and elongated to butyric, and examined by spectroscopy and molecular mechanics computations for an ability to form conformation-determining hydrogen bonds. With m designating the number of conjoining CH2 units and n indicating the number of CH2 units of the alkanoic acid chains of ( m.n)-homorubins, (2.1)-, (3.2)-, (4.2)-, and (4.3)-homorubins were prepared and compared with previously synthesized (2.2) and (2.3), which adopt intramolecularly hydrogen-bonded conformations in CHCl3.
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
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Page/Page column 17, (2010/02/08)
The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
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Page 13, (2010/02/10)
The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.
Elegant synthesis of novel pyrroles and dipyrrylmethane of biosynthetic importance
Singh, Vandana,Baqi, Abdul
, p. 701 - 702 (2007/10/03)
Ethyl 4-ethoxycarbonylmethyl-3,5-dimethylpyrrole-2-carboxylate (1) has been synthesized by extension and modification of Knorr pyrrole synthesis. Its acetoxymethyl derivative (2) has also been synthesized. Diethyl 3,3′-bis(ethoxycarbonylmethyl)-4,4′-dimethyl-2,2′ -dipyrrylmethane-5,5′-dicarboxylate has been synthesized by self-condensation of 2.
Synthesis of some novel porphyrins
Singh, Vandana,Baqi, Abdul
, p. 908 - 910 (2007/10/03)
2,3,6,7-Tetra(2-methoxycarbonylethyl)-1,4,5,8-tetramethyiporphin [coproporphyrin II, tetramethyl ester] (9) and 2,3-di(2-methoxycarbonylethyl)-6,7-dimethoxycarbonylmethyl-1,4,5, 8-tetramethylporphin] a new synthetic coproporphyrin] (10) were synthesized by condensing 3,3′-dimethoxycarbonylethyl)-4,4′-dimethyl-2,2′ -dipyrrylmethane-5,5′-dicarboxylic acid (5) with 3,3′ -di(2-ethoxycarbonylethyl)-5,5′-diformyl-4,4′-dimethyl-2, 2′-dipyrrylmethane (6) and 3,3′-dicarboxymethyl-4,4′ -dimethyl-2,2′-dipyrrylmethane-5,5′-dicarboxylic acid (8) with 6, respectively. Tetra-substituted pyrroles for synthesizing appropriate dipyrrylmethanes were synthesized in good yields by extension and modification of Knorr synthesis.
Synthesis and acidity constants of 13CO2H-labelled mono and dipyrrole carboxylic acids. pKa from 13C-NMR
Holmes, Darren L.,Lightner, David A.
, p. 1607 - 1622 (2007/10/02)
Six monocarboxylic acids were prepared highly enriched with 13C in their CO2H groups, and their pKa values were determined at low concentrations 10-4-10-5 M in H2O and in H2O-(CD3)2SO mixtures by analysis of pH-dependent 13CO2H NMR chemical shifts. Plots of the variation of CO2H(CO2-) 13C-NMR chemical shift vs pH gave a typical titration curve from which pKa's for [1-13C]-phenylpropionic (1) and [1-13C]-phenylacetic (2) acids were determined to be 4.60 and 4.16 respectively in H2O, and 4.67 and 4.31 respectively in H2O-27% vol (CD3)2SO. Bilirubin analogs, xanthobilirubic acid (5) and nor-xanthobilirubic acid (6) were determined to have pKa values of 4.76 and 4.64 respectively in H2O-27% vol (CD3)2SO, and extrapolated to pKa values and 4.62 and 4.51 in H2O.
