403517-07-7Relevant academic research and scientific papers
A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones
Jaganmohan, Chikkanti,Vinay Kumar,Venkateshwarlu,Mohanty, Sandeep,Kumar, Jaydeep,Venkateswara Rao,Raghunadh, Akula,Tadiparthi, Krishnaji
supporting information, p. 2163 - 2170 (2020/06/10)
A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.
De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds
Jaganmohan, Chikkanti,Vinay Kumar,Sandeep Reddy,Mohanty, Sandeep,Kumar, Jaydeep,Venkateswara, Rao,Tadiparthi, Krishnaji,Raghunadh, Akula
supporting information, p. 168 - 174 (2018/01/01)
A new versatile and efficient strategy for the synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazoline-4(1H)-one compounds has been developed by one-pot multicomponent reaction with isatoic anhydride, amines followed by in situ-generated Vilsmeier reagent. The reaction has also been studied with different amines and solvents.
Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties
Kirincich, Steven J.,Xiang, Jason,Green, Neal,Tam, Steve,Yang, Hui Y.,Shim, Jaechul,Shen, Marina W.H.,Clark, James D.,McKew, John C.
experimental part, p. 4383 - 4405 (2009/10/23)
The synthesis and optimization of a class of trisubstituted quinazoline-2,4(1H,3H)-dione cPLA2α inhibitors are described. Utilizing pharmacophores that were found to be important in our indole series, we discovered inhibitors with reduced lipophilicity and improved aqueous solubility. These compounds are active in whole blood assays, and cell-based assay results indicate that prevention of arachidonic acid release arises from selective cPLA2α inhibition.
