40353-60-4Relevant academic research and scientific papers
Synthesis, characterization, and study the inhibitory effect of thiazole and thiadiazole derivatives toward the corrosion of copper in acidic media
Tomi, Ivan Hameed R.,Al-Daraji, Ali H. R.,Aziz, Sherien A.
, (2015)
The authors describe the synthesis and characterization of two different five-member heterocycle derivatives (thiazole and thiadiazole) by several organic procedures. These compounds were characterized by FTIR, 1H NMR, and elemental analyses. A
Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors
Bai, Li-gai,Cao, Fei,Han, Chuang,Jian, Meng-Meng,Ma, Zheng-Yue,Xu, Yuan,Yang, Kan
, (2020)
A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Moreover, the IC50 value of compound 4f was to 0.66 μM, which was higher than that of Rivastigmine and Huperzine-A as reference compounds, and it had a weak inhibitory effect on butyrylcholinesterase. The potential binding mode of compound 4f with AChE was investigated by the molecular docking, and the results showed that 4f was strongly bound up with AChE with the optimal conformation, in addition, their binding energy reached ?11.27 Kcal*mol?1. At last, in silico molecular property of the synthesized compounds were predicted by using Molinspiration online servers. It can be concluded that the lead AChEIs compound 4f presented satisfactory drug-like characteristics.
A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase
Heng, Sabrina,Gryncel, Kimberly R.,Kantrowitz, Evan R.
experimental part, p. 3916 - 3922 (2009/10/02)
The identification of a proper lead compound for fructose 1,6-bisphosphatase (FBPase) is a critical step in the process of developing novel therapeutics against type-2 diabetes. Herein, we have successfully generated a library of allosteric inhibitors against FBPase as potential anti-diabetic drugs, of which, the lead compound 1b was identified through utilizing a virtual high-throughput screening (vHTS) system, which we have developed. The thiazole-based core structure was synthesized via the condensation of α-bromo-ketones with thioureas and substituents on the two aryl rings were varied. 4c was found to inhibit pig kidney FBPase approximately fivefold better than 1b. In addition, we have also identified 10b, a tight binding fragment, which can be use for fragment-based drug design purposes.
