40358-33-6

Basic information

• Product Name: 2,3,4,5-TETRAHYDRO-1,5-BENZOTHIAZEPINE
• Synonyms: 2,3,4,5-tetrahydro-1,5-benzothiazepine hydrobromide;2,3,4,5-TETRAHYDRO-1,5-BENZOTHIAZEPINE(WXG03173)
• CAS NO: 40358-33-6
• Molecular Formula: C₉H₁₁NS
• Molecular Weight: 165.26
• Mol File: 40358-33-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 290.6°C at 760 mmHg
• Flash Point: 129.5°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: 1.582
• PKA: 4.47±0.20(Predicted)
• CAS DataBase Reference: 2,3,4,5-TETRAHYDRO-1,5-BENZOTHIAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-TETRAHYDRO-1,5-BENZOTHIAZEPINE(40358-33-6)
• EPA Substance Registry System: 2,3,4,5-TETRAHYDRO-1,5-BENZOTHIAZEPINE(40358-33-6)

Safety Data

• Hazardous Substances Data: 40358-33-6(Hazardous Substances Data)

Usage

Uses

2,3,4,5-Tetrahydro-1,5-benzothiazepine is a reactant in the preparation of substituted 3,3-difluoro-2-oxindoles via intramolecular C-H difluoroalkylation.

InChI:InChI=1/C9H11NS/c1-2-5-9-8(4-1)10-6-3-7-11-9/h1-2,4-5,10H,3,6-7H2

Upstream product

• 68253-35-0 indan-1-one oxime 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 26235-49-4 N-(thiochroman-4-yl)hydroxylamine 
• 15857-68-8 (E)-thiochroman-4-one oxime 
• 137-07-5 2-amino-benzenethiol 
• 109-64-8 1,3-dibromo-propane 
• 15857-68-8 thiochroman-4-one oxime 
• 6320-02-1 o-bromothiophenol 

Downstream Products

• 384832-29-5 5-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1,5-benzothiazepine 
• 58121-91-8 2,3,4,5-Tetrahydro-1,5-benzothiazepin hydrochloride 
• 92962-62-4 N-benzoyl-2,3,4,5-tetrahydro-1,5-benzothiazepine 

Relevant articles and documents

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Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents

A series of benzenesulfonamide derivatives were synthesized and evaluated for their anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferative and tubulin polymerization. Compound BA-3b proved to be the most potent compound with IC50value ranging from 0.007 to 0.036 μM against seven cancer cell lines, and three drug-resistant cancer cell lines, which indicated a promising anti-cancer agent. The target tubulin was also verified by dynamic tubulin polymerization assay and tubulin intensity assay.

Regiospecific rearrangement of hydroxylamines to secondary amines using diisobutylaluminum hydride

A systematic investigation of a reductive ring-expansion reaction of N-monosubstituted hydroxylamines with diisobutylaluminum hydride (DIBALH) was carried out. The reaction regiospecifically provided a variety of bicyclic or tricyclic heterocycles or linear secondary amines containing nitrogen attached to an aromatic ring. The Japan Institute of Heterocyclic Chemistry.