40359-43-1

Usage

Used in organic synthesis

The compound is used as a building block or reactant in the synthesis of more complex organic molecules.
Building block in the production of various pharmaceuticals and agrochemicals The compound is used as a starting material in the production of various drugs and chemicals used in agriculture.

4-bromo-butoxy group

A common substituent in organic chemistry This functional group is often used to introduce specific properties or functionalities into a molecule.

Benzaldehyde

A common aromatic aldehyde This functional group is a building block for the synthesis of other aromatic compounds and is used as a flavoring agent and in the production of dyes, perfumes, and other aromatic compounds.

Attached to a benzene ring

This indicates that the 4-bromo-butoxy group is attached to a benzene ring, which is a six-carbon ring with delocalized electrons, making it a useful building block for the synthesis of more complex molecules.

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-02-8 salicylaldehyde 

Downstream Products

• 102040-70-0 Toluene-4-sulfonic acid 4-(2-formyl-phenoxy)-butyl ester 
• 151056-16-5 2-[4-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-butoxy]-benzaldehyde 
• 151056-14-3 2-[4-(6-Amino-purin-9-yl)-butoxy]-benzaldehyde 
• 102040-65-3 C₆₂H₆₆N₄O₈S₂ 
• 102060-17-3 C₆₂H₇₂N₄O₈S₂ 
• 1194807-93-6 C₉₆H₁₁₂O₂₀ 
• 52032-55-0 Br^(1-)*C₂₉H₂₈O₂P⁽¹⁺⁾ 
• 1293405-14-7 C₄₄H₄₅BrN₄O₄ 
• 1293405-11-4 3,5-bis{4-(2-formylphenoxy)butoxy}bromobenzene 
• 1424631-43-5 C₂₇H₃₀N₂O₁₀ 
• 1428269-55-9 C₂₃H₂₆N₂O₇ 
• 1428269-43-5 2-(4-(nitrooxy)butoxy)benzoic acid 
• 1428269-40-2 4-(2-formylphenoxy)butylnitrate 

Relevant academic research and scientific papers

Synthesis and photochromic properties of disulfide-1,3-diazabicyclo[3.1.0] hex-3-ene functionalized silver nanoparticles

The new 1,3-diazabicyclo[3.1.0]hex-3-ene derivative with disulfide bond to modify silver nanoparticle (AgNP) surface was synthesized. The photochromism of the packed ligand on AgNPs showed a pronounced bathochromic shift in the absorption band of the open ring photoisomers and also in the surface plasmon resonance absorption (SPRA) of AgNPs.

Regioselective synthesis of spiropyrrolidine/spiropyrrolizidine/ spirothiazolidine-grafted macrocycles through 1,3-dipolar cycloaddition methodology

Synthesis of 13- and 16-membered macrocyclic enone with alkyl ether and triazole as a linker was achieved using intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloadd

Halogen-Bonding Strapped Porphyrin BODIPY Rotaxanes for Dual Optical and Electrochemical Anion Sensing

Anion receptors employing two distinct sensory mechanisms are rare. Herein, we report the first examples of halogen-bonding porphyrin BODIPY [2]rotaxanes capable of both fluorescent and redox electrochemical sensing of anions. 1H NMR, UV/visibl

The one-pot synthesis of butyl-1H-indol-3-alkylcarboxylic acid derivatives in ionic liquid as potent dual-acting agent for management of BPH

Based on the SAR of both α1-AR antagonists and 5α-reductase (5AR) inhibitors, the dual-acting agent 4-(1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-indol-3-yl)butanoic acid 4aaa was designed against BPH and synthesized by two steps of N-alkylation. One-pot protocol towards 4aaa was newly developed. With IL [C6min]Br as solvent, the yield of 4aaa was increased to 75.1% from 16.0% and the reaction time was shortened in 1.5 h from 48 h. 25 derivatives structurally based on arylpiperazine and indolyl butyric acid with alkyl linker were prepared. The protocol was futher extended to get another 14 derivatives wherein O-alkylation was involved, and applied to the synthesis of biologically efficient molecules DPQ and Aripiprazole. Expectedly, compound 4aaa exhibited dual inhibition of α1-AR and 5α-reductase, and exhibited no obvious cytotoxicity against human cells. The pharmacokinetic properties of 4aaa was also determined.

NSAIDs DERIVATIVES AND USES THEREOF

The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions ther

Regio- and stereoselective synthesis of spiro-pyrrolidine/pyrrolizidine/ thiazolidine-grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction

Regioselective synthesis of spiropyrrolidine-grafted 11-membered macrocycle was accomplished through an intramolecular [3+2] cycloaddition of azomethine ylides. The key precursor alkenyl diketone (4a-b) was obtained from simple starting materials. The dipole generated from isatin tethered to O-alkyl enone (4a-b) was reacted intramolecularly to yield the spiropyrrolidine-grafted macrocycles (6a-b). The structures of the cycloadducts were assigned by 2D NMR and confirmed by single crystal analysis.

Synthesis of thiophene and NO-curcuminoids for antiinflammatory and anti-cancer activities

In search of better NSAIDs four novel nitric oxide donating derivatives of curcumin (compounds 9a-d), and four thiophene curcuminoids (compounds 10a-c, 11) have been synthesised. The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1β, TNF-α and chemokine CXCL-8 were evaluated using human monocytic THP-1 and colon adenocarcinoma CACO-2 cell lines. All of the nitric oxide donating curcuminoids 9a-d and the thiophene curcuminoids 10a-c and 11 were non-cytotoxic to THP-1 cells over a concentration range of 10-100 μM and compared with curcumin compounds 10b and 10c, were more toxic. In CACO-2 cells, 10b and 11 appeared to be non-toxic at 10 to 50 μM, whereas 10a and 10c were non-cytotoxic at 10 μM only. These results clearly indicate that the introduction of a nitroxybutyl moiety to curcumin and replacement of phenyl rings with thiophene units reduces the cytotoxic effect of the parent curcumin, whereas a methyl substituted thiophene increases the cytotoxic effects. In THP-1 cells, drugs 10a and 11 significantly decreased IL-1-β production at their non-cytotoxic concentrations, whereas, they did not decrease TNF-α production in CACO-2 cells. Compound 11 showed a significant decrease in CXCL-8 production.

Synthesis and biological evaluation of nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide as potential antiplatelet agents

A series of novel nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide were designed, synthesized and evaluated as potential antiplatelet agents. Compound 10b significantly inhibited the adenosine diphosphate (ADP)-induced platelet aggregation

Synthesis of a doubly strapped light-harvesting porphyrin bearing energy donor molecules hanging on to the straps: An attempt toward macroscopic control over molecular conformation that affects the efficiency of fluorescence resonance energy transfer

We report here the synthesis of a light-harvesting molecule 1, in which 5,5'-diphenyl-2,2'-bithiophene units (energy donors) and a doubly strapped porphyrin (energy acceptor) are three-dimensionally connected through four alkyl chains to form a "universal

The adverse effect of benzannelation on the aromaticity of oxocinyl anion: A combined experimental and theoretical study

A synthesis of 2H-1-benzoxocin from readily available compounds was accomplished. The potentially 'aromatic' π-excessive systems 2H-1-benzoxocinyl and 6H-dibenz[b,f]oxocinyl anions were generated from their corresponding conjugate acid precursors 7c and 8, respectively. It was found that 2H-1-benzoxocinide 3d lacks the type of π-frame stability associated with the parent 2H-oxocinide 1d and that the dibenzo analog 5b is more unstable than 3d. Both 3d and 5b undergo rapid structural reorganization to form their corresponding stable isomeric anions. We were able to characterize the proton-quenched products of these anions as the ring-opened structures 15 and 18, respectively. 1H-NMR and an ab initio calculation at the 6-31g* level indicated that, unlike the 'aromatic' parent 2H-oxocinide 1d and the aza analog 3c, 3d incorporates a non-planar oxocinyl ring in which the negative charge is primarily localized on the pentadienyl moiety of the ring, but also partial delocalization of π-electron density onto the benzene ring occurs.