403612-37-3

Upstream product

• 403612-36-2 (4-Benzyloxy-2-vinylphenoxy)acetic Acid Ethyl Ester 

Downstream Products

• 638214-60-5 ethyl [(4-{[1-(6-bromo-2-pyridinyl)pentyl]oxy}-2-ethylphenyl)oxy]acetate 
• 403612-38-4 {2-Ethyl-4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}acetic Acid Ethyl Ester 
• 638215-67-5 ({2-ethyl-4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid 
• 638215-65-3 ({2-ethyl-4-[(1-{6-[4-(ethyloxy) phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid 
• 638215-66-4 {[4-({1-[6-(4-cyanophenyl)-2-pyridinyl]pentyl}oxy)-2-ethylphenyl]oxy}acetic acid 
• 638215-64-2 {[4-({1-[6-(4-chlorophenyl)-2-pyridinyl] pentyl}oxy)-2-ethylphenyl]oxy}acetic acid 
• 638215-63-1 [(2-ethyl-4-{[1-(6-phenyl-2-pyridinyl)pentyl]oxy}phenyl)oxy]acetic acid 
• 863119-46-4 ethyl {[2-ethyl-4-({5-(methyloxy)-3-[3-methyl-6-(trifluoromethyl)-1-benzothien-2-yl]pentyl}oxy)phenyl]oxy}acetate 
• 863119-26-0 ethyl {[2-ethyl-4-({3-[3-methyl-6-(trifluoromethyl)-1-benzothien-2-yl]heptyl}oxy)phenyl]oxy}acetate 
• 863119-22-6 ethyl {[2-ethyl-4-({3-[3-methyl-6-(trifluoromethyl)-1-benzothien-2-yl]hexyl}oxy)phenyl]oxy}acetate 

Relevant academic research and scientific papers

COMPOUND WITH AGITATION EFFECT ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR , AND PREPARATION METHOD AND USE THEREOF

The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype δ (PPARδ), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPARδ thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.

COMPOUND WITH AGITATION EFFECT ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR. PROCESS FOR ITS PREPARATION AND USE THEREOF

The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype δ (PPARδ), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPARδ thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.

Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists

Compounds represented by the following (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (II), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubsituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl. R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.