403615-35-0

Upstream product

• 1775-95-7 2-amino-5-nitrobenzophenone 

Downstream Products

• 1597602-19-1 2-(2-fluoro-4-nitrophenyl)-5-nitrobenzophenone 
• 1597602-28-2 2-(2-fluoro-3-methylphenyl)-5-nitrobenzophenone 
• 1597602-26-0 2-(2-fluoro-3-pyridyl)-5-nitrobenzophenone 
• 1597602-24-8 2-(2-chloro-5-nitrophenyl)-5-nitrobenzophenone 
• 1597602-17-9 2-(2-fluoro-5-methoxyphenyl)-5-nitrobenzophenone 
• 1597602-13-5 2-(2-fluoro-4-bromophenyl)-5-nitrobenzophenone 
• 1597602-12-4 2-(2-fluorophenyl)-5-nitrobenzophenone 
• 1597602-46-4 C₂₆H₂₇FN₂O₂ 
• 1597602-43-1 C₂₄H₂₄FN₃O₂ 
• 1597602-41-9 C₂₅H₂₄ClN₃O₄ 
• 1597602-39-5 C₂₆H₂₆FN₃O₅ 
• 1597602-37-3 C₂₆H₂₇FN₂O₃ 
• 1597602-32-8 C₂₅H₂₄BrFN₂O₂ 
• 1597602-30-6 C₂₅H₂₅FN₂O₂ 

Relevant academic research and scientific papers

An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides

A direct transformation of ortho-alkynylated aromatic vinyl ethers to 1-iodonaphthalenes and other iodo-heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.

Copper-catalyzed cascade cyclization of 1,5-enynes: Via consecutive trifluoromethylazidation/diazidation and click reaction: Self-assembly of triazole fused isoindolines

Copper-catalyzed cascade cyclization of 1,5-enynes with two types of hypervalent reagents was developed via consecutive trifluoromethylazidation/diazidation and intramolecular click reaction (CUAAC), providing one-pot self-assembly of triazole fused isoindolines bearing a trifluoromethyl or an azide moiety. Moreover, the construction of a trifluoromethylcyclopropyl unit, which has been considered as a metabolically stable replacement for a tert-butyl moiety and was difficult to access, was also achieved under trifluoromethylazidation conditions. All these reactions exhibited excellent chemoselectivity, good to excellent yields and broad functional group tolerance.

Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange

(Chemical Equation Presented) Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below -40°C and do not undergo electron-transfer reactions. They react as expected with various electrophiles.

Highly chemoselective hydrogenolysis of iodoarenes

The catalytic hydrodehalogenation reaction using molecular hydrogen and Pd/C has been revisited. It is shown that the speed of removal of halogen increases with increasing electronegativity I Br Cl. Nevertheless, selective dehydrohalogenation in compounds containing other reducible functions can be achieved only with iodine and not with bromine or chlorine. Selective deiodination of iodobenzophenone could be accomplished without reducing the carbonyl group. Hydrogenolysis of azidoiodoaromatic compounds to the corresponding azido compounds is high yielding. This selectivity was exploited for the labeling of benzophenone- and azido-containing compounds by deuterium and tritium.