403706-59-2Relevant academic research and scientific papers
High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
Cholewiak, Agnieszka,Adamczyk, Kamil,Kopyt, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
supporting information, p. 4365 - 4371 (2018/06/22)
The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.
Reversal of enantioselectivity by tuning the conformational flexibility of phase-transfer catalysts
Hua, Ming-Qing,Cui, Han-Feng,Wang, Lian,Nie, Jing,Ma, Jun-An
supporting information; experimental part, p. 2772 - 2776 (2010/07/03)
(Figure Presented) Towards perfect asymmetric catalysis: When binol-derived N-spiro quaternary ammonium salts were used as phase-transfer catalysts in the conjugate addi-tion of nitroalkanes to chalcones and its analogues, an intriguing reversal of enan-t
