403736-61-8

Basic information

• Product Name: [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester
• Synonyms: [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester
• CAS NO: 403736-61-8
• Molecular Weight: 507.611
• Mol File: 403736-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester(403736-61-8)
• EPA Substance Registry System: [2-benzyloxycarbonylamino-6-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-hexanoylamino]-acetic acid tert-butyl ester(403736-61-8)

Safety Data

• Hazardous Substances Data: 403736-61-8(Hazardous Substances Data)

Upstream product

• 403736-53-8 N_α-carbobenzyloxy-N_ε-9-fluorenylmethoxycarbonyl-L-lysylglycin tert-butyl ester 
• 41218-40-0 5-chloro-3-methoxy-[1,2,4]thiadiazole 
• 403736-57-2 N_α-carbobenzyloxy-L-lysylglycin tert-butyl ester 
• 105751-18-6 N_α-carbobenzyloxy-N_ε-9-fluorenylmethoxycarbonyl-L-lysine 
• 27532-96-3 glycine tert-butyl ester hydrochloride 

Relevant articles and documents

Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase.

Herein we report the synthesis and evaluation of 14 novel peptides as potential irreversible inactivators of guinea pig liver transglutaminase (TGase). These peptides were designed to resemble Cbz-L-Gln-Gly, known to be a good TGase substrate, and to include a 1,2,4-thiadiazole group. The side chain length of the amino acid residue bearing the inhibitor group was also varied in order to permit investigation of this effect. Their inactivation rate constants were measured using a direct continuous spectrophotometric method and were found to vary between 0.330 to 0.89 microM(-1) min(-1).