403739-82-2

Basic information

• Product Name: Benzoic acid, 2-fluoro-, 2-[[(4-chlorophenyl)amino]carbonyl]-1-(1,1-dimethylethyl)hydrazide
• CAS NO: 403739-82-2
• Molecular Formula: C18H19ClFN3O2
• Molecular Weight: 363.819
• Mol File: 403739-82-2.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-fluoro-, 2-[[(4-chlorophenyl)amino]carbonyl]-1-(1,1-dimethylethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-fluoro-, 2-[[(4-chlorophenyl)amino]carbonyl]-1-(1,1-dimethylethyl)hydrazide(403739-82-2)
• EPA Substance Registry System: Benzoic acid, 2-fluoro-, 2-[[(4-chlorophenyl)amino]carbonyl]-1-(1,1-dimethylethyl)hydrazide(403739-82-2)

Safety Data

• Hazardous Substances Data: 403739-82-2(Hazardous Substances Data)

Upstream product

• 104-12-1 p-chlorphenylisocyanate 
• 340821-90-1 2-fluoro-benzoic acid N-tert-butyl-hydrazide 
• 403739-68-4 N'-tert-butyl-N'-(2-fluoro-benzoyl)-hydrazinecarboxylic acid benzyl ester 

Relevant articles and documents

A Convenient Synthesis of Novel N′-tert-Butyl-N′-Substituted Benzoyl-N-(Substituted Phenyl)aminocarbonylhydrazines and Their Derivatives

N-tert-butyl-N-substituted benzoylhydrazines were prepared in two convenient procedures with good yields, subsequent reaction with substituted phenylisocyanates in 1,2-dichloroethane provided a series of novel N′-tert-butyl-N‰-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines. Further treatment with oxalyl chloride gave their derivatives in good yields. The title compounds exhibit moderate larvicidal activities and anticancer activities.

Synthesis and biological activity of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives

Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities.