40380-68-5Relevant academic research and scientific papers
Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression
Frycia, Anne,Starck, Jean-Philippe,Jadot, Sophie,Lallemand, Benedicte,Leclercq, Karine,Brutto, Patrick Lo,Matagne, Alain,Verbois, Valerie,Mercier, Joel,Kenda, Benoit
, p. 200 - 205 (2010)
(Chemical Equation Presented) Capitalizing on the proven clinical efficacy of levetiracetam as an antiepileptic drug, a drug discovery program lead to the identification of a new generation of SV2A ligands with equal or better tolerability profiles than levetiracetam, and improved potency toward seizure suppression in animal models.
4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives
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Paragraph 0649; 0722, (2015/01/06)
The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4′, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES
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Page/Page column 77; 93, (2013/08/15)
The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4', R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
THIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS
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Page/Page column 111, (2008/06/13)
The invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, which are antagonist of the CXCR3 chemokine receptor useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.
