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40397-96-4

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40397-96-4 Usage

General Description

4-CHLORO-3-NITROPHENYL ISOCYANATE is a chemical compound with the molecular formula C7H3ClN2O3. It is an isocyanate derivative that contains a chloro and nitro group attached to a phenyl ring. 4-CHLORO-3-NITROPHENYL ISOCYANATE is highly reactive and is commonly used in chemical synthesis and manufacturing processes, particularly in the production of pharmaceuticals and agricultural chemicals. It is a potent irritant to the skin, eyes, and respiratory system, and proper safety precautions must be taken when handling this compound. Additionally, it is important to note that 4-CHLORO-3-NITROPHENYL ISOCYANATE is toxic and poses health and environmental risks if not properly managed and disposed of.

Check Digit Verification of cas no

The CAS Registry Mumber 40397-96-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,3,9 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40397-96:
(7*4)+(6*0)+(5*3)+(4*9)+(3*7)+(2*9)+(1*6)=124
124 % 10 = 4
So 40397-96-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H3ClN2O3/c8-6-2-1-5(9-4-11)3-7(6)10(12)13/h1-3H

40397-96-4 Well-known Company Product Price

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  • Alfa Aesar

  • (L11087)  4-Chloro-3-nitrophenyl isocyanate, 94%   

  • 40397-96-4

  • 1g

  • 261.0CNY

  • Detail
  • Alfa Aesar

  • (L11087)  4-Chloro-3-nitrophenyl isocyanate, 94%   

  • 40397-96-4

  • 5g

  • 1066.0CNY

  • Detail

40397-96-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-3-nitrophenyl Isocyanate

1.2 Other means of identification

Product number -
Other names Isocyanic Acid 4-Chloro-3-nitrophenyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40397-96-4 SDS

40397-96-4Relevant articles and documents

Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer

Akwii, Racheal,Alvina, Karina,Ashraf-Uz-Zaman, Md,Farshbaf, Mohammad Jodeiri,German, Nadezhda A.,Kallem, Raja Reddy,Mikelis, Constantinos M.,Putnam, William,Sajib, Md Sanaullah,Shahi, Sadisna,Trippier, Paul C.,Wang, Wei,Zhang, Ruiwen

, (2020/10/12)

Triple-negative breast cancer (TNBC) is an aggressive type of cancer characterized by higher metastatic and reoccurrence rates, where approximately one-third of TNBC patients suffer from the metastasis in the brain. At the same time, TNBC shows good responses to chemotherapy, a feature that fuels the search for novel compounds with therapeutic potential in this area. Recently, we have identified novel urea-based compounds with cytotoxicity against selected cell lines and with the ability to cross the blood-brain barrier in vivo. We have synthesized and analyzed a library of more than 40 compounds to elucidate the key features responsible for the observed activity. We have also identified FGFR1 as a molecular target that is affected by the presence of these compounds, confirming our data using in silico model. Overall, we envision that these compounds can be further developed for the potential treatment of metastatic breast cancer.

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