40398-00-3

Usage

Uses

Used in Chemical Synthesis:
2-CHLORO-4-METHYLPHENYL ISOCYANATE 97 is used as a building block in the synthesis of various polymers and resins. Its strong reactivity and unique structure make it a valuable component in the creation of new materials with specific properties.
Used in Polyurethane Production:
In the polyurethane industry, 2-CHLORO-4-METHYLPHENYL ISOCYANATE 97 is used as a key component in the production of polyurethane materials. These materials are known for their versatility and are used in a wide range of applications, including insulation, coatings, adhesives, and flexible foams.
Used in Industrial Material Production:
2-CHLORO-4-METHYLPHENYL ISOCYANATE 97 is also used in the production of other industrial materials, where its strong reactivity and unique structure can contribute to the development of new products with specific properties and applications.
Safety Precautions:
Due to its potential hazards and irritant properties, it is important to handle 2-CHLORO-4-METHYLPHENYL ISOCYANATE 97 with care. Proper safety measures should be taken to minimize exposure and ensure the safe use of this chemical compound in various applications.

InChI:InChI=1/C8H6ClNO/c1-6-2-3-8(10-5-11)7(9)4-6/h2-4H,1H3

Upstream product

• 51085-51-9 4-methyl-2-chloroaniline hydrochloride 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 40397-46-4 2-Hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-chloro-4-methyl-phenyl)-amide 
• 85601-53-2 C₁₂H₁₇ClN₄O₂ 
• 1260404-49-6 1-(2-chloro-4-methylphenyl)-3-(3-ethyl-1-(4-methoxyphenyl)pent-1-yn-3-yl)urea 
• 85601-63-4 C₁₄H₂₀ClN₅O₃ 
• 85601-73-6 1-(2-Chloro-4-methyl-phenyl)-3-(4-hydroxy-3,5,5-trimethyl-2-oxo-imidazolidin-1-yl)-urea 
• 247075-29-2 N-[4-(daunorubicin-N-carbonyloxymethyl)-2-chlorophenyl] O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranuronosyl) carbamate 
• 247075-28-1 N-[4-(hydroxymethyl)-2-chlorophenyl] O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranuronosyl) carbamate 
• 247075-27-0 N-[4-(bromomethyl)-2-chlorophenyl] O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranuronosyl) carbamate 
• 247075-26-9 N-(4-methyl-2-chlorophenyl) O-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranuronosyl) carbamate 
• 56462-10-3 1-amidino-3-(2-chloro-4-methylphenyl)urea 

Relevant academic research and scientific papers

Novel anthracycline-spacer-β-glucuronide, -β-glucoside, and -β-galactoside prodrugs for application in selective chemotherapy

A series of anthracycline prodrugs containing an immolative spacer was synthesized for application in selective chemotherapy. The prodrugs having the general structure anthracycline-spacer-β-glycoside were designed to be activated by β-glucuronidase or β-galactosidase. Prodrugs with -chloro, -bromo or -n-hexyl substituents on the spacer were synthesized as well as prodrugs containing a -β-glucuronyl, -β-glucosyl or -β-galactosyl carbamate specifier. The key step in the synthesis of all prodrugs is the highly β-diastereoselective addition reaction of the anomeric hydroxyl of a glycosyl donor to a spacer isocyanate resulting in the respective β-glycosyl carbamate pro-moieties. The resulting protected pro-moieties were coupled to an anthracycline. Prodrugs were evaluated with respect to activation rate by the appropriate enzyme and additionally, their IC50 values were determined. Optimal prodrugs in this study were at least 100- to 200-fold less toxic than their corresponding drug in vitro and were activated to the parent drug in a half-life time of approximately 2h. Copyright (C) 1999 Elsevier Science Ltd.

Parasiticidal new substituted thienopyranones

Parasiticidal new substituted thienopyranones of the formula STR1 in which X represents O or S, R1 and R2 independently of one another represent hydrogen, halogen, CN, NO2, alkyl, aralkyl, aryl, alkylcarbonyl or alkoxycarbonyl, or, together with the adjacent C atoms, form a carbocyclic ring which is optionally interrupted by heteroatoms, R3 represents optionally substituted alkyl or phenyl, R4 represents hydrogen or alkyl, R3 and R4, together with the adjacent nitrogen atom, represent a heterocyclic 5- or 6-membered ring. Some of the intermediates for making them are also new.