404018-08-2

Basic information

• Product Name: 1H-Indole-3-propanoic acid, 1-[(4-fluorophenyl)methyl]-, (4-fluorophenyl)methyl ester
• CAS NO: 404018-08-2
• Molecular Formula: C25H21F2NO2
• Molecular Weight: 405.444
• Mol File: 404018-08-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-propanoic acid, 1-[(4-fluorophenyl)methyl]-, (4-fluorophenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-propanoic acid, 1-[(4-fluorophenyl)methyl]-, (4-fluorophenyl)methyl ester(404018-08-2)
• EPA Substance Registry System: 1H-Indole-3-propanoic acid, 1-[(4-fluorophenyl)methyl]-, (4-fluorophenyl)methyl ester(404018-08-2)

Safety Data

• Hazardous Substances Data: 404018-08-2(Hazardous Substances Data)

Upstream product

• 830-96-6 Indole-3-propionic acid 

Downstream Products

• 219544-69-1 3-<1-(4-fluorobenzyl)indol-3-yl>propionic acid 

Relevant articles and documents

Synthesis and pharmacological evaluation of (indol-3-yl)alkylamides as potent analgesic agents

A series of (indol-3-yl)alkylamides was synthesized and evaluated for analgesic activity. Two N-(pyridin-4-yl)acetamides, compounds 24 and 25, bearing benzyl or 4-fluorobenzyl moieties in 1-position of indole ring exhibited promising analgesic properties (ED50 = 8.1 and 11 mg/kg p.o., respectively), being as potent as the reference drugs flupirtine (CAS 56995-20-1), ibuprofen (CAS 15687-27-1) and diclofenac (CAS 15307-86-5). The two test compounds were tested for their anti-inflammatory activity by carrageenin-induced edema in rat paw test. 4-Fluorobenzyl derivative 25 whose ID50 was 0.085 ± 0.021 mmol/kg was selected as a lead compound for further pharmacomodulation.