40403-72-3 Usage
Uses
Used in Pharmaceutical and Agrochemical Industries:
2-(Chloromethyl)imidazole is utilized as a key intermediate in the synthesis of various pharmaceutical and agrochemical products, contributing to the development of new drugs and pesticides. Its chemical properties allow for the creation of a diverse array of compounds with therapeutic and protective applications.
Used in Electrically Conductive Polymers Production:
In the polymer industry, 2-(Chloromethyl)imidazole is employed as a component in the production of electrically conductive polymers. Its incorporation enhances the electrical properties of these polymers, broadening their use in electronic and optoelectronic devices.
Used in Corrosion Inhibitors Manufacturing:
2-(Chloromethyl)imidazole serves as a vital ingredient in the manufacturing of corrosion inhibitors. Its presence in these inhibitors helps to protect metals from degradation, extending the lifespan of structures and equipment in various industries.
Used as a Reagent in Organic Synthesis:
In the field of organic synthesis, 2-(Chloromethyl)imidazole is used as a reagent to facilitate various chemical reactions. Its unique properties enable the synthesis of complex organic compounds for research and commercial applications.
Given the potential health hazards and environmental impacts associated with 2-(Chloromethyl)imidazole, it is crucial to implement careful handling and disposal procedures to mitigate risks and ensure safety in all applications.
Check Digit Verification of cas no
The CAS Registry Mumber 40403-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,4,0 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 40403-72:
(7*4)+(6*0)+(5*4)+(4*0)+(3*3)+(2*7)+(1*2)=73
73 % 10 = 3
So 40403-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H5ClN2/c5-3-4-6-1-2-7-4/h1-2H,3H2,(H,6,7)
40403-72-3Relevant academic research and scientific papers
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility
Ang, Chee Wei,Tan, Lendl,Sykes, Melissa L.,Abugharbiyeh, Neda,Debnath, Anjan,Reid, Janet C.,West, Nicholas P.,Avery, Vicky M.,Cooper, Matthew A.,Blaskovich, Mark A. T.
, p. 15726 - 15751 (2020/12/02)
Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.
PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS
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, (2008/06/13)
The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.
PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS
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, (2008/06/13)
The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
