40430-66-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethylyladamantane is used as an antiviral agent for the treatment and prevention of influenza A virus infections. It functions by inhibiting the activity of the viral M2 protein, which is crucial for the virus's ability to enter host cells and replicate. This action effectively reduces the severity and duration of influenza symptoms, especially when administered within 48 hours of the onset of symptoms.
1-ETHYNYLADAMANTANE is also valued for its generally well-tolerated nature and low potential for causing adverse effects when used according to the recommended dosage guidelines. This makes 1-Ethylyladamantane a significant component in the management of influenza A virus infections, contributing to the overall health and well-being of individuals affected by the virus.

Upstream product

• 67886-48-0 Phosphoric acid (Z)-1-adamantan-1-yl-2-benzenesulfonyl-vinyl ester diphenyl ester 
• 768-90-1 1-Adamantyl bromide 
• 2094-74-8 1-Adamantanecarbaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 770-71-8 1-adamantanemethanol 
• 82094-48-2 1-(trimethylsilylethynyl)adamantane 
• 768-92-3 1-adamantyl fluoride 
• 1066-54-2 trimethylsilylacetylene 
• 67886-39-9 1-(1-adamant-1-yl)-2-phenylsulfonylethanone 
• 1660-04-4 1-acetyladamantane 
• 828-51-3 1-Adamantanecarboxylic acid 
• 67886-63-9 1-(1-Adamantyl)-1-(diethoxyphosphinyl)-oxyethen 
• 67886-48-0 Phosphoric acid (Z)-1-adamantan-1-yl-2-benzenesulfonyl-vinyl ester diphenyl ester 
• 91800-98-5 1-(2,2-dibromoethynyl)adamantane 

Downstream Products

• 922497-19-6 1-{[4-(difluoromethoxy)phenyl]ethynyl}adamantane 
• 1660-04-4 1-acetyladamantane 
• 101698-55-9 1-Oxo-1--3,3-diphenyl-propen-(2) 
• 922496-78-4 1-(4-methoxyphenyl)-2-tricyclo[3.3.1.1(3,7)]dec-1-ylethane-1,2-dione 

Relevant academic research and scientific papers

PREPARATION OF 1,3-DIALKYNYLADAMANTANES AND THEIR ALUMINIUM BROMIDE-MEDIATED CYCLOADDITION ADDUCTS

The synthesis of 1,3-diethynyl- (1) and 1,3-di(1-propynyl)adamantane (2)is reported.The aluminium bromide induced cocyclodimerization of 2 with propyne affords the dinuclear ? complex 7, and the cyclodimerization of 1 the polynuclear ? complex 8.

Formation of Nucleophilic Allylboranes from Molecular Hydrogen and Allenes Catalyzed by a Pyridonate Borane that Displays Frustrated Lewis Pair Reactivity

Here we report the in situ generation of nucleophilic allylboranes from H2 and allenes mediated by a pyridonate borane that displays frustrated-Lewis-pair reactivity. Experimental and computational mechanistic investigations reveal that upon H2 activation, the covalently bound pyridonate substituent becomes a datively bound pyridone ligand. Dissociation of the formed pyridone borane complex liberates Piers borane and enables a hydroboration of the allene. The allylboranes generated in this way are reactive towards nitriles. A catalytic protocol for the formation of allylboranes from H2 and allenes and the allylation of nitriles has been devised. This catalytic reaction is a conceptually new way to use molecular H2 in organic synthesis.

Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization

Herein, we present a facile synthesis of three azide-functionalized fluorophores and their covalent attachment as triazoles in Huisgen-type cycloadditions with model alkynes. Besides two ortho- and para-bromo-substituted benzaldehydes, the azide functionalization of a fluorene-based structure will be presented. The copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) of the so-synthesized azide-functionalized bromocarbaldehydes with terminal alkynes, exhibiting different degrees of steric demand, was performed in high efficiency. Finally, we investigated the photophysical properties of the azide-functionalized arenes and their covalently linked triazole derivatives to gain deeper insight towards the effect of these covalent linkers on the emission behavior.

Preparation of isoquinazolines: Via metal-free [4 + 2] cycloaddition of ynamides with nitriles

TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner. A rapid and efficient strategy has been employed for the syntheses of alkyl-substituted 1,2-dihydroquinazoline derivatives, and it exhibits good functional group tolerance, has a short reaction time, shows excellent diastereoselectivity, and is a simple and high-yielding reaction.

METAL ION-INCLUDING FULLERENE DERIVATIVE AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a metal ion-including fullerene derivative having a functional group which can have properties according to a wide range of uses and a method for producing the same. SOLUTION: The present invention provides a metal ion-including fullerene derivative in which a diene compound having a functional group having desired properties is introduced into a metal ion-including fullerene or a salt thereof. The functional group has properties including a dye, a catalyst, photoreactivity, water solubility, and the like. The metal ion-including fullerene derivative is described in claim 1. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2019,JPOandINPIT

Aluminum-Catalyzed Cross-Coupling of Silylalkynes with Aliphatic C-F Bonds

We report the generation of aliphatic and benzylic acetylenes via reaction of primary, secondary, and tertiary aliphatic fluorides with various trimethylsilyl acetylides. These reactions are catalyzed by Al and B Lewis acids, most effectively by the extre

A mild preparation of alkynes from alkenyl triflates

We report herein a protocol for preparing alkynes from alkenyl triflates. Stoichiometric LiCl promotes this transformation in DMF at ambient temperature. A range of terminal and internal alkynes were obtained smoothly. A one-pot procedure of alkyne format

SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)

The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biologica

SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)

The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biologica

Substituted homoallenyl aldehydes and their derivatives. Part 1: Homoallenyl aldehydes and protected hydrazones

The paper presents a simple synthesis of substituted propargyl vinyl ethers and their subsequent thermally-initiated Claisen rearrangement leading to various 3-substituted homoallenyl aldehydes. Several methods, including Sonogashira coupling, base-promoted substitution on the triple bond by sodium amide or butyllithium, and the preparation of substituted propargyl alcohols, were used in the initial step. Phosphate-protected homoallenyl aldehyde hydrazone derivatives were synthesised and fully characterised. The stereochemistry of 9-anthracene carbaldehyde hydrazone, which, surprisingly, afforded both cis and trans isomers, was established using X-ray analysis.