404356-22-5Relevant academic research and scientific papers
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninergic ligands
Mésangeau, Christophe,Pérès, Basile,Descamps-Fran?ois, Carole,Chavatte, Philippe,Audinot, Valérie,Coumailleau, Sophie,Boutin, Jean A.,Delagrange, Philippe,Bennejean, Caroline,Renard, Pierre,Caignard, Daniel H.,Berthelot, Pascal,Yous, Sa?d
, p. 3426 - 3436 (2010)
Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and various aryl units are linked via a linear alkyl chain through the methoxy group. The compounds were tested for their actions at melatonin receptors. Several of these liga
Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same
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Page 7, (2010/02/05)
The invention relates to compound of formula (I): wherein: B represents hydrogen, COOR, CONRR′, or (C1-C6)alkyl substituted by COOR, CONRR′, or OR, G1 represents —X′—(CH2)n—X—(CH2)m—X″—chain wherein X, X′, X″, n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G2 represents alkylene chain as defined in the description, and A represents NRCOR′, NRCSR′, CONRR′, CSNRR′, NRCONR′R″, or NRCSNR′R″, and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
