404356-54-3Relevant academic research and scientific papers
Syntheses of differentially protected isocoumarins
Lowell, Andrew N.,Wall, Philip D.,Waters, Stephen P.,Kozlowski, Marisa C.
experimental part, p. 5573 - 5582 (2010/10/01)
Syntheses of an isocoumarin subunit suitable for the completion of purpuromycin are outlined. Specifically, work targeting an orthogonally protected isocoumarin (eventually 12% yield over 12 steps) and an improved synthesis of a symmetrically protected isocoumarin (18% over 10 steps) are described. A new modification for selective catechol protection as mediated by potassium bicarbonate is also presented along with insights into oxidative and reductive functionalization of isocoumarins.
Studies in the total synthesis of heliquinomycinone: Proof of concept and assembly of a fully mature spirocyclization precursor
Qin, Donghui,Ren, Rex X.,Siu, Tony,Zheng, Changsheng,Danishefsky, Samuel J.
, p. 4709 - 4713 (2007/10/03)
A strategy for the synthesis of heliquinomycin, a selective helicase inhibitor, hinges on the spirocyclization of precursor 3. Naphthofuran 1 and aldehyde 2 were readily prepared and used in the synthesis of 3. The key steps in the total synthesis of heli
