404367-47-1

Upstream product

• 20017-46-3 2,3,5,6-tetrafluoro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)pyridine 
• 700-16-3 Pentafluoropyridine 
• 536-74-3 phenylacetylene 
• 259875-80-4 2,6-dibromo-3,5-difluoro-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)pyridine 

Relevant academic research and scientific papers

Multi-substituted heterocycles

Pentafluoropyridine was used as the starting material for the preparation of a range of pyridine derivatives that bear five different substituents. In this context, syntheses of penta-functional pyridine systems by sequences of nucleophilic aromatic substitution, palladium catalysed coupling and bromo-lithiation processes are described.

Polyhalogenated heterocyclic compounds. Part 47. Syntheses of multi-substituted pyridine derivatives from pentafluoropyridine

A sequence of nucleophilic aromatic substitution and palladium catalysed coupling processes were used to transform pentafluoropyridine into various pyridine derivatives that bear five different functional groups.