404849-99-6Relevant academic research and scientific papers
Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria
Nunnery, Joshawna K.,Engene, Niclas,Byrum, Tara,Cao, Zhengyu,Jabba, Sairam V.,Pereira, Alban R.,Matainaho, Teatulohi,Murray, Thomas F.,Gerwick, William H.
, p. 4198 - 4208 (2012/06/18)
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curacao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
