404868-30-0Relevant academic research and scientific papers
Chiral oxazoline NNP type ligands as well as synthesis method and application thereof
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Paragraph 0275; 0276; 0277; 0278, (2017/08/28)
The invention relates to chiral oxazoline NNP type ligands as well as a synthesis method and an application thereof. The ligands adopt the structure shown in general formula 1 or 2. During preparation, a chiral ligand 1 and a chiral ligand 2 are prepared from Fmoc-Cl and a chiral amino acid compound 3 used as initial raw materials through multi-step reactions. The ligands can be applied to catalytic synthesis of chiral beta ketone ester fluoride and synthesis of propanedione derivatives and chiral malonate derivatives through palladium-catalyzed asymmetric allyl substitution reactions. Compared with the prior art, the reaction condition is mild, operation is easy, repeatability is good, mass preparation can be realized, and the prepared catalyst has higher ee value and yield when applied to beta ketone ester fluoridation and palladium-catalyzed asymmetric allyl substitution reactions.
Development of chiral terminal-alkene-phosphine hybrid ligands for palladium-catalyzed asymmetric allylic substitutions
Liu, Zhaoqun,Du, Haifeng
supporting information; experimental part, p. 3054 - 3057 (2010/08/19)
A variety of novel chiral terminal-alkene-phosphine hybrid ligands were successfully developed from diethyl l-tartrate for palladium-catalyzed asymmetric allylic alkylations, etherifications, and amination to give the desired products in excellent yields and ees.
Asymmetric hydrogenation and allylic substitution reaction with novel chiral pinene-derived N,P-ligands
Meng, Xiangyan,Li, Xinsheng,Xu, Dongcheng
experimental part, p. 1402 - 1406 (2009/12/01)
A series of new chiral tetrahydroquinoline ligands, derived from chiral α-pinene, were successfully synthesized. Iridium and palladium complexes of these ligands were proven to be efficient catalysts for enantioselective hydrogenation and allylic substitution reactions with moderate to excellent enantioselectivities (90-95% ee) and high yields.
