404869-77-8

Basic information

• Product Name: 3-(4-Chlorophenyl)-3-(1H-pyrrol-1-yl)propanoic acid
• Synonyms: 3-(4-Chlorophenyl)-3-(1H-pyrrol-1-yl)propanoic acid;3-(4-Chloro-phenyl)-3-pyrrol-1-yl-propionic acid
• CAS NO: 404869-77-8
• Molecular Formula: C₁₃H₁₂ClNO₂
• Molecular Weight: 249.7
• Mol File: 404869-77-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Chlorophenyl)-3-(1H-pyrrol-1-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chlorophenyl)-3-(1H-pyrrol-1-yl)propanoic acid(404869-77-8)
• EPA Substance Registry System: 3-(4-Chlorophenyl)-3-(1H-pyrrol-1-yl)propanoic acid(404869-77-8)

Safety Data

• Hazardous Substances Data: 404869-77-8(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 

Relevant articles and documents

Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43

The 2-aryl-3-indoleacetamides FGIN-1-27 and FGIN-1-43 have already been characterized in-vitro as potent and specific ligands for the mitochondrial DBI receptor. This affinity was associated with psychotropic properties in several rodent behavioural tasks (in particular anxiolytic action) via enhancement of GABA transmission through neurosteroid production. The synthesis of new 3-aryl-3-pyrrol-1-ylpropanamides 1a-i, analogues of FGIN-1-27 and FGIN-1-43, is described in four steps starting from the corresponding arylaldehydes. Preliminary evaluation of these compounds in behavioural studies (spontaneous locomotor activity and anxiolytic activity) in mice was also undertaken.