4049-01-8Relevant academic research and scientific papers
Preparation method for sulfanilamide-6-methoxy pyrimidine sodium
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Paragraph 0020-0022, (2017/01/23)
The present invention discloses a preparation method for a sulfanilamide-6-methoxy pyrimidine sodium-hydrate. The method specifically comprises the steps of: under the action of an organic base and pyridine, carrying out a reaction on 4-acetamido benzene sulfonyl chloride and 4-amino-6-methoxy pyrimidine to generate 4-acetamido benzene sulfanilamide-6-methoxy pyrimidine; then salifying with sodium hydroxide; and after decoloration treatment by activated carbon, cooling, crystallizing, filtrating and drying the product to obtain the sulfanilamide-6 a methoxy pyrimidine sodium hydrate. In the preparation method, a one-pot method is used for preparing sulfanilamide-6-methoxy pyrimidine sodium. Compared with the prior art at home, the synthetic steps are greatly simplified; furthermore, in the method provided by the invention, 4-MP and SCL are used as raw materials, occurrence of side reactions in a process of synthesizing sulfanilamide-6-methoxy pyrimidine sodium is avoided, thus effectively improving the yield of the product.
