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1-(4-fluoro-phenoxy)-propan-2-ol, also known as 1-(4-fluorophenoxy)-2-propanol or 4'-fluoropropranolol, is an organic compound with the molecular formula C9H11FO2. It is a colorless liquid at room temperature and is characterized by its unique combination of a phenolic ring with a fluorine atom, an ether linkage, and a secondary alcohol group. This chemical is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of beta-blockers, which are drugs used to treat conditions such as hypertension and angina. The presence of the fluorine atom can significantly influence the compound's reactivity and physical properties, making it a valuable building block in the development of new molecules with specific therapeutic effects.

405-77-6

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405-77-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405-77-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 405-77:
(5*4)+(4*0)+(3*5)+(2*7)+(1*7)=56
56 % 10 = 6
So 405-77-6 is a valid CAS Registry Number.

405-77-6Downstream Products

405-77-6Relevant academic research and scientific papers

Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes

Hao, Hong-Yan,Mao, Yang-Jie,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian

supporting information, p. 2396 - 2402 (2020/03/13)

Selective C(sp3)-C(sp2) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp3)-H and C(sp2)-H bonds represents an attractive alternative toward new C(sp3)-C(sp2) bonds. Herein, we establish a selective inter-and intramolecular C(sp3)-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of β-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo-and regioselectivity.

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