405060-95-9 Usage
Uses
Used in Research Applications:
Salubrinal is used as a research tool for studying the effect of stress-protective genes and pathways on organism development and lifespan. It is also used to investigate the therapeutic potential of salubrinal in methamphetamine-induced blood-brain barrier disruption.
Used in Pharmaceutical Applications:
1. Salubrinal is used as an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleepand wake-regulatory neurons.
2. Salubrinal is used as a specific inhibitor of ER Stress induced apoptosis, protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and preventing replication of herpes virus (IC50 = 3 μM) by inhibiting dephosphorylation of eIF2α.
Used in Osteoporosis Research:
Salubrinal is being studied for its effects in osteoporosis, as eIF2α has a role in bone formation.
Used in Neuroprotective Research:
Salubrinal also shows potential neuroprotective actions and is being investigated for its therapeutic value in this area.
References
1. https://en.wikipedia.org/wiki/Salubrinal
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en®ion=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html
References
1) Boyce?et al. (2005)?A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress; Science,?307?935
2) Kessel (2006)?Protection of Bcl-2 by salubrinal; Biochem. Biophys. Res. Commun.,?346?1320
3) He?et al. (2013)?Osteoporosis regulation by salubrinal through eFI27alpha; mediated differentiation of osteoclast and osteoblast; Cell. Signal.,?25?552
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).
Biochem/physiol Actions
Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Check Digit Verification of cas no
The CAS Registry Mumber 405060-95-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,0,6 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 405060-95:
(8*4)+(7*0)+(6*5)+(5*0)+(4*6)+(3*0)+(2*9)+(1*5)=109
109 % 10 = 9
So 405060-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
