405103-02-8

Basic information

• Product Name: 3-PYRIDINAMINE, 6-(1-METHYLETHYL)-
• Synonyms: 3-PYRIDINAMINE, 6-(1-METHYLETHYL)-;6-(1-Methylethyl)-3-Pyridinamine;3-Pyridinamine,6-(1-methylethyl)-(9CI);3-Amino-6-isopropylpyridine;6-Isopropylpyridin-3-amine;6-(propan-2-yl)pyridin-3-aMine;5-AMino-2-isopropylpyridine;6-lsopropylpyridin-3-aMine
• CAS NO: 405103-02-8
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• Product Categories: PYRIDINE;Pyridines
• Mol File: 405103-02-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255.135 °C at 760 mmHg
• Flash Point: 131.787 °C
• Appearance: /
• Density: 1.009 g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.77±0.10(Predicted)
• CAS DataBase Reference: 3-PYRIDINAMINE, 6-(1-METHYLETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINAMINE, 6-(1-METHYLETHYL)-(405103-02-8)
• EPA Substance Registry System: 3-PYRIDINAMINE, 6-(1-METHYLETHYL)-(405103-02-8)

Safety Data

• Hazardous Substances Data: 405103-02-8(Hazardous Substances Data)

Usage

Uses

6-Isopropylpyridin-3-amine is used to prepare quinolinonecarboxamides as modulators of ATP-binding cassette transporters.

InChI:InChI=1/C8H12N2/c1-6(2)8-4-3-7(9)5-10-8/h3-6H,9H2,1-2H3

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 131941-21-4 2-isopropyl-5-nitropyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 886214-82-0 tert-butyl (6-isopropylpyridin-3-yl)carbamate 

Downstream Products

• 2332897-85-3 (S)-4-(2,5-difluorophenyl)-2-(3-fluoropyrrolidin-1-yl)-N-(6-isopropylpyridin-3-yl)nicotinamide 
• 405103-04-0 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide 

Relevant articles and documents

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE

A compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate thereof or a solvate thereof, which shows not only a C5a receptor antagonistic activity but also high activity in the biological availability, as