40513-35-7

Usage

InChI:InChI=1/C10H13NO/c1-8(12)10(11)7-9-5-3-2-4-6-9/h2-6,10H,7,11H2,1H3

Upstream product

• 5463-26-3 3-acetylamino-4-phenyl-2-butanone 
• 917-58-8 potassium ethoxide 
• 150-30-1 Phenylalanine 
• 860312-99-8 1-(N-tert.-butyloxycarbonyl-amino)-2-(S)-phenylethyl methyl ketone 

Downstream Products

• 10325-00-5 N-<1-Benzyl-2-oxo-propyl>-acrylsaeureamid 
• 87253-19-8 N-(1-Benzyl-2-oxo-propyl)-2-(4-methoxy-phenyl)-acetamide 
• 62025-69-8 (3,6-dimethylpyrazine-2,5-diyl)bis(phenylmethanone) 
• 187144-61-2 N-(1-benzyl-2-hydroxy-propyl)-benzamide 
• 87253-22-3 5-benzylidene-3-phenyl-4-methylpyrrolin-2-one 
• 87253-37-0 5-benzylidene-3-phenyl-4-methylpyrrolin-2-one 
• 87253-23-4 5-Benzyl-5-ethoxy-4-methyl-3-phenyl-1,5-dihydro-pyrrol-2-one 
• 87253-25-6 3-(4-Methoxy-phenyl)-4-methyl-5-[1-phenyl-meth-(Z)-ylidene]-1,5-dihydro-pyrrol-2-one 
• 87253-31-4 5-Benzyl-3-(4-chloro-phenyl)-4-methyl-1,5-dihydro-pyrrol-2-one 
• 87253-35-8 5-Benzyl-5-hydroxy-4-methyl-3-phenyl-1,5-dihydro-pyrrol-2-one 
• 87253-24-5 3-(4-Chloro-phenyl)-4-methyl-5-[1-phenyl-meth-(Z)-ylidene]-1,5-dihydro-pyrrol-2-one 
• 87253-30-3 5-Benzyl-4-methyl-3-phenyl-1,5-dihydro-pyrrol-2-one 
• 78631-22-8 dibenzyl-2,5 dimethyl-3,6 pyrazine 
• 87253-17-6 N-(1-Benzyl-2-oxo-propyl)-2-phenyl-acetamide 

Relevant academic research and scientific papers

Peptide inhibitors of IκB protease: Modification of the C-termini of Z-LLF-CHO

A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-κB through inhibition of IκB protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compounds 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of IκB protease can have an effect on various signalling pathways.