405173-83-3

Usage

Molecular weight

196.63 g/mol

Structure

Benzimidazole derivative with a chloromethyl group and a methoxy group attached to the benzene ring

Usage

Organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active compounds

Potential applications

Materials science, reagent in chemical reactions

Specific properties and uses

Vary depending on the context and application in which it is used.

Upstream product

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Relevant academic research and scientific papers

PYRAZOLOTRIAZINES

The present invention provides compounds of general formula (I), in which X, R1, R2 and R3 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders such as cancer disorders, as a sole agent or in combination with other active ingredients.

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).