40521-06-0

Usage

Uses

Used in Agricultural and Horticultural Industries:
(2S)-2-(2,4,5-trichlorophenoxy)propanoic acid is used as a selective post-emergent herbicide for controlling broadleaf weeds in various agricultural and horticultural crops. Its application helps to protect and enhance crop yields by reducing competition from unwanted plants.
However, due to concerns over its potential environmental and health impacts, the use of (2S)-2-(2,4,5-trichlorophenoxy)propanoic acid has been restricted and discontinued in some countries. This has led to the development and adoption of alternative, more environmentally friendly herbicides and weed management practices.

Upstream product

• 93-72-1 2-(2,4,5-trichlorophenoxy)propanoic acid 
• 57-24-9 strychnidin-10-one 
• 95-95-4 2,4,5-trichlorophenol 
• 66423-07-2 (R)-2-(2,4,5-Trichlorphenoxy)propionsaeure-ethylester 

Relevant academic research and scientific papers

Separation of the phenoxy acid herbicides and their enantiomers by capillary zone electrophoresis in presence of highly sulphated cyclodextrins

The study of the chiral compounds and their fate in the environment is receiving an increasing attention - enantiomeric ratios are being measured and enantioselective degradation processes are being reported. It is particularly important with the toxic compounds like the pesticides, which are being freely used in the environment to control the harmful pests. Capillary zone electrophoresis was used for the chiral and mutual separation of four phenoxy acid herbicides using highly sulphated cyclodextrins (HSCD) in the buffer. The CE runs were performed with reverse polarity (anode in the outlet vial) using the acidic ammonium formate buffer (20 mmol, pH 3). Under these conditions of suppressed the electroendoosmotic flow (EOF), the analytes are mobilized to the anode by entering into host guest relation with the migrating negatively charged sulphated cyclodextrin. The phenoxy acid herbicides selected for the purpose were fenoprop, dicloprop, mecoprop and 2,4-DB. The α-HSCD and β-HSCD have been tested as resolving agents in the CE for the separation of the enantiomers of the herbicides. Though the chiral separation of the dicloprop and mecoprop were achieved with α-HSCD but it was not able to resolve fenoprop. With β-HSCD the required base line separation was achieved. Potential difference selected was 10 kV. The limit of detection (S/N=3) achieved in present case is 0.15 ppm for fenoprop, 0.14 ppm for dicloprop and mecoprop and 0.11 ppm for 2,4-DB.

Substitution of 2-(Sulfonyloxy)carboxylates with Oxygene and Sulfur Nucleophiles without Racemization

The ethyl 2-(sulfonyloxy)propionates (S)-1a-c react with phenolates formed from 2 and with carboxylates 8 to give the respective 2-(aryloxy)- (R)-3 and 2-(acyloxy)propionates (R)-9 with inversion of configuration.Due to the high leaving tendency of the triflate group, (S)-1a generally give higher yields of substitution products under milder conditions than the corresponding mesylate (S)-1b and tosylate (S)-1c.In the case of the reaction of malic and succinic acid derivatives only the triflate (S)-10a is converted to the acyloxy compounds (R)-12 with carboxylates 8 atlow temperature (-45 deg C); with the mesylates 10b and the bromide 10d only elimination is observed.Mercaptides and thiophenolates formed from 17 react with (S)-1a-c analogously.With potassium thiocyanate 1a,b react almost exclusively to give the thiocyanate 19; only traces of the corresponding isothiocyanate 20 are obtained.