405219-34-3

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE
• Synonyms: 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE
• CAS NO: 405219-34-3
• Molecular Formula: C₈H₈ClFO₂S
• Molecular Weight: 222.66
• Mol File: 405219-34-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE(405219-34-3)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE(405219-34-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 405219-34-3(Hazardous Substances Data)

Usage

Type of compound

sulfonamide derivative and sulfonyl chloride

Physical appearance

colorless to pale yellow liquid

Odor

pungent

Reactivity

highly reactive due to the presence of the sulfonyl chloride functional group

Common uses

reagent in organic synthesis, building block in pharmaceutical industry, production of agrochemicals and other fine chemicals

Safety precautions

causes severe skin and eye irritation, should be used in a well-ventilated area with proper personal protective equipment.

Upstream product

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Downstream Products

• 455267-24-0 C-{1-[2-(4-Fluoro-phenyl)-ethanesulfonyl]-piperidin-4-yl}-methylamine 
• 1104022-28-7 {6-[2-(4-fluoro-phenyl)-ethanesulfonyl]-5,6,7,8-tetrahydro-[2,6]naphthyridin-1-yl}-quinolin-3-yl-amine 

Relevant articles and documents

Functional group divergence and the structural basis of acridine photocatalysis revealed by direct decarboxysulfonylation

The reactivity of the sulfonyl group varies dramatically from nucleophilic sulfinates through chemically robust sulfones to electrophilic sulfonyl halides—a feature that has been used extensively in medicinal chemistry, synthesis, and materials science, especially as bioisosteric replacements and structural analogs of carboxylic acids and other carbonyls. Despite the great synthetic potential of the carboxylic to sulfonyl functional group interconversions, a method that can convert carboxylic acids directly to sulfones, sulfinates and sulfonyl halides has remained out of reach. We report herein the development of a photocatalytic system that for the first time enables direct decarboxylative conversion of carboxylic acids to sulfones and sulfinates, as well as sulfonyl chlorides and fluorides in one step and in a multicomponent fashion. A mechanistic study prompted by the development of the new method revealed the key structural features of the acridine photocatalysts that facilitate the decarboxylative transformations and provided an informative and predictive multivariate linear regression model that quantitatively relates the structural features with the photocatalytic activity.

Towards Uniform Iodine Catalysis: Intramolecular C?H Amination of Arenes under Visible Light

A photochemical catalytic amination of arenes is presented. The reaction proceeds under benign iodine catalysis in the presence of visible light as the initiator and provides access to a range of differently substituted arylamines. A total of 29 examples demonstrate the broad applicability of this mild oxidation method. The scope of the reaction could further be expanded to silyl-tethered derivatives, which undergo intramolecular amination upon formation of seven-membered heterocycles. Cleavage of the silicon tether provides access to the corresponding 3-substituted anilines.

New pyridazine endothelin antagonists

Compounds of formula (I), pharmaceutical formulations thereof and the use of such compounds for treating endothelin mediated diseases or conditions are described herein. The compounds of the present invention have affinity for endothelin receptors, are se