405263-88-9

Upstream product

• 306776-73-8 α-bromosuccinic acid-1-tertbutylester-4-benzyl ester 
• 88850-36-6 2-bromo-succinic acid 4-benzyl ester 
• 2177-63-1 (S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 306776-75-0 1,4,7,10-tetraazacyclododec-1-yl-butanedioic acid 1-(1,1-dimethylethyl)4-(phenylmethyl)ester 

Relevant academic research and scientific papers

A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling

New DOTA-based bifunctional prochelators, e.g., 1-(1-carboxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10 -tetraazacyclodode-cane (DOTAGA(tBu)4), (6d) for a broad application in the modification of biomolecules with metal ions were prepared. The five-step synthesis of 6d has an overall yield of about 20%. The coupling of 6d to a bioactive peptide on solid-phase was exemplified with use of a CCK-B (cholecystokinin) analogue. (C) 2000 Elsevier Science Ltd.