40527-43-3

Basic information

• Product Name: 4-(diethoxymethyl)-1,2-dimethoxybenzene
• CAS NO: 40527-43-3
• Molecular Formula: C₁₃H₂₀O₄
• Molecular Weight: 240.2955
• Mol File: 40527-43-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 293.7°C at 760 mmHg
• Flash Point: 91.3°C
• Density: 1.03g/cm³
• Vapor Pressure: 0.00298mmHg at 25°C
• Refractive Index: 1.482
• CAS DataBase Reference: 4-(diethoxymethyl)-1,2-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(diethoxymethyl)-1,2-dimethoxybenzene(40527-43-3)
• EPA Substance Registry System: 4-(diethoxymethyl)-1,2-dimethoxybenzene(40527-43-3)

Safety Data

• Hazardous Substances Data: 40527-43-3(Hazardous Substances Data)

Upstream product

• 78-10-4 tetraethoxy orthosilicate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 64-17-5 ethanol 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 82734-41-6 1,1,5-Triethoxy-5-(3,4-dimethoxyphenyl)-2-pentene 
• 82724-72-9 1,1,5,9-Tetraethoxy-9-(3,4-dimethoxyphenyl)-2,6-nonadiene 
• 69922-36-7 2-(3,4-dimethoxyphenyl)-1,3-dithiolane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1454574-38-9 3,5-dichloro-N-((3,4-dimethoxy)benzylidene)pyridin-4-amine 
• 82724-71-8 1-(3',4'-Dimethoxyphenyl)-1,3,3-triethoxypropan 
• 92397-09-6 α,α-bis(7-hydroxy-5-isopropyltropon-2-yl)-3,4-dimethoxytoluene 

Relevant articles and documents

Practical acetalization and transacetalization of carbonyl compounds catalyzed by recyclable PVP-I

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields.

Synthesis of Alkylphenols and -catechols from Plectranthus albidus (Labiatae)

In the preceding paper, we described the isolation and structure elucidation of a series of even-numbered phenol- or pyrocatechol-derived 1-arylalkane-5-ones.To establish the assigned structures unambiguously and to have larger quantities available for physiological testing, the following compounds were prepared: in the alkylphenol series, 1-(4'-hydroxyphenyl)tetradecan-5-one (2a), 1-(4'-hydroxyphenyl)hexadecan-5-one (2b), and 1-(4'-hydroxyphenyl)octadecan-5-one (2c); in the alkylcatechol series, 1-(3',4'-dihydroxyphenyl)decan-5-one (3a; not isolated as a natural compound), 1-(3',4'-dihydroxyphenyl)dodecan-5-one (3b), 1-(3',4'-dihydroxyphenyl)tetradecan-5-one (3c), 1-(3',4'-dihydroxyphenyl)hexadecan-5-one (3d), 1-(3',4'-dihydroxyphenyl)octadecan-5-one (3e), and 1-(3',4'-dihydroxyphenyl)icosan-5-one (3f); in the alkenylphenol series, (Z)-1-(4'-hydroxyphenyl)octadec-13-en-5-one (4a) and (E)-1-(4'-hydroxyphenyl)octadec-13-en-5-one (4b); in the alkenylcatechol series, (E,E)-1-(3',4'-dihydroxyphenyl)deca-1,3-dien-5-one (1) and (Z)-1-(3',4'-dihydroxyphenyl)octadec-13-en-5-one (5).All compounds proved to be identical with the previously assigned structures.Compound 1 was synthesized by regioselective aldol condensation of heptan-2-one with (E)-3-(3',4'-dimethoxyphenyl)prop-2-enal (6d; Scheme 1), the phenols 2a-c and the catechols 3a-f by addition of the corresponding alkyl Grignard reagent to 5-(4'-methoxyphenyl)- or 5-(3',4'-dimethoxyphenyl)pentanal (17c and 18c, resp.; Scheme 4), and the olefins 4a, 4b and 5 from 17c or 18c via the 9-O-silyl-protected 13-(4'-methoxyphenyl)- or 13-(3',4'-dimethoxyphenyl)tridecanals (26 and 27, resp.) and Wittig olefination as the key steps (Scheme 5).