405274-57-9Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of novel 3-(2-(4h-1,2,4-triazol-4-yl)ethyl)-1-alkyl-1h-indole derivatives
Liu, Chuan-Feng,Zhang, Hong-Jian,Quan, Zhe-Shan
, p. 833 - 839 (2016/09/23)
A series of novel 3-[2-(4H-1,2,4-triazol-4-yl)ethyl]-1-alkyl-1H-indole derivatives (4a-s) were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using maximal electroshock (MES) and rotarod neurotoxicity (TOX) tests. Among the compounds studied, compound 3-[2-(4H-1,2,4-triazol-4-yl)ethyl]-1-nonyl-1H-indole (4p) was found by intraperitoneal (i.p.) administration in mice to be the most potent compound with a median effective dose (ED50) value of 10.2 mg/kg, possessed better anticonvulsant activity and higher safety than carbamazepine.
Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition
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Page/Page column 23, (2010/02/06)
The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.
