405282-15-7

Basic information

• Product Name: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-pyridinylcarbon yl)-
• CAS NO: 405282-15-7
• Molecular Formula: C36H34N4O7
• Molecular Weight: 634.689
• Mol File: 405282-15-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-pyridinylcarbon yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-pyridinylcarbon yl)-(405282-15-7)
• EPA Substance Registry System: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-pyridinylcarbon yl)-(405282-15-7)

Safety Data

• Hazardous Substances Data: 405282-15-7(Hazardous Substances Data)

Upstream product

• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 78983-37-6 C₂₇H₂₂N₆O₇ 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 78983-36-5 4-N-picolyl-2'-deoxycytidine 

Relevant articles and documents

Facile synthesis of oligonucleotides on solid support using pyridine derivatives for amino and phosphate protection

The picolinoyl group has been used for amino protection in the case of all the three deoxynucleosides-dC, dA and dG, and good yields of N-protected nucleosides are obtained. This pyridine derivative along with another pyridine derivative, viz. (α-pyridyl) methyl, an autocatalytic phosphate protecting group, has been used successfully in the synthesis of two oligonucleotides, d(TACGTTTTGCT) and d(ACCGATATCGT) following solid phase methodology. The good yields of these 11-mers (48 and 45%, respectively) are attributed to the greater solubilising effect generated due to the combination of these two groups. The structures of these oligomers have been confirmed by enzymatic hydrolysis with snake venom phosphodiesterase followed by alkaline phosphatase.