405299-07-2Relevant academic research and scientific papers
Electronic and medium effects on the rate of arene C-H bond activation by cationic Ir(III) complexes
Tellers, David M.,Yung, Cathleen M.,Arndtsen, Bruce A.,Adamson, Dan R.,Bergman, Robert G.
, p. 1400 - 1410 (2002)
A detailed mechanistic study of arene C-H activation in CH2Cl2 solution by Cp*(L)IrMe(X) [L = PMe3, P(OMe)3; X = OTf, (CH2Cl2)BArf; (BArf = B[3,5-C6H3 (CF3)2]4)-] is presented. It was determined that triflate dissociation in Cp*(L)IrMe(OTf), to generate tight and/or solvent-separated ion pairs containing a cationic iridium complex, precedes C-H activation. Consistent with the ion-pair hypothesis, the rate of arene activation by Cp*(L)IrMe(OTf) is unaffected by added external triflate salts, but the rate is strongly dependent upon the medium. Thus the reactivity of Cp* (PMe3)IrMe(OTf) can be increased by almost 3 orders of magnitude by addition of (n-Hex)4NBArf, presumably because the added BArf anion exchanges with the OTf anion in the initially formed ion pair, transiently forming a cation/borate ion pair in solution (special salt effect). In contrast, addition of (n-Hex)4NBArf to [Cp*PMe3Ir(Me)CH2Cl2][BArf] does not affect the rate of benzene activation; here there is no initial covalent/ionic preequilibrium that can be perturbed with added (n-Hex)4NBArf. An analysis of the reaction between Cp*(PMe3)IrMe(OTf) and various substituted arenes demonstrated that electron-donating substituents on the arene increase the rate of the C-H activation reaction. The rate of C6H6 activation by [Cp*(PMe3)Ir(Me)CH2Cl2] [BArf] is substantially faster than [Cp*(P(OMe)3)Ir(Me)CH2Cl2] [BArf]. Density functional theory computations suggest that this is due to a less favorable preequilibrium for dissociation of the dichloromethane ligand in the trimethyl phosphite complex, rather than to a large electronic effect on the C-H oxidative addition transition state. Because of these combined effects, the overall rate of arene activation is increased by electron-donating substituents on both the substrate and the iridium complex.
