405517-55-7

Upstream product

• 80-41-1 2-chloroethyl tosylate 
• 405517-54-6 2-iodo-4-(trifluoromethoxy) phenol 

Downstream Products

• 405517-64-8 (2R,3S)-3-(4-Bromo-benzoyloxy)-3-[2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-allyl]-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1027911-11-0 (2R,3S)-3-[(S)-2-(2-Cyclopropoxy-5-trifluoromethoxy-phenyl)-3-methanesulfonyloxy-propyl]-3-hydroxy-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 405517-66-0 (2R,3S)-3-[2-(2-Cyclopropoxy-5-trifluoromethoxy-phenyl)-allyl]-2-phenyl-3-trimethylsilanyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 405517-65-9 (2R,3S)-3-[(S)-2-(2-Cyclopropoxy-5-trifluoromethoxy-phenyl)-3-hydroxy-propyl]-3-hydroxy-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 405517-63-7 (2R,3S)-3-[2-(2-Cyclopropoxy-5-trifluoromethoxy-phenyl)-allyl]-3-hydroxy-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 405517-70-6 (3S,5S,6R)-3-(2-Cyclopropoxy-5-trifluoromethoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester 
• 405517-61-5 methanesulfonic acid 2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-allyl ester 
• 405517-57-9 1,3-dichloro-2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-propan-2-ol 
• 405517-62-6 2-(1-bromomethyl-vinyl)-1-cyclopropoxy-4-trifluoromethoxy-benzene 
• 405517-59-1 2-chloromethyl-2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-oxirane 
• 405517-58-0 1-chloro-2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-propan-2-ol 
• 405517-60-4 2-(2-cyclopropoxy-5-trifluoromethoxy-phenyl)-prop-2-en-1-ol 

Relevant academic research and scientific papers

AZABICYCLIC AMINE DERIVATIVES AS NK-1 RECEPTOR ANTAGONISTS

The present invention relates compounds of the formula (I), wherein X represents hydrogen or a C1-4alkyl group optionally substituted by a hydroxy group; Y represents hydrogen, C1-6alkyl or C3-7cycloalkyl; Z is -CR9/

Stereocontrolled preparation of a nonpeptidal (-)-spirobicyclic NK-1 receptor antagonist

The synthesis of a spirobicyclic NK-1 receptor (Substance-P) antagonist 1 antipode is described. Retrosynthetic analysis reveals an allylic halide A bearing the cyclopropoxy-substituted aryl group and a 2-phenyl-3-piperidone B. The stereochemistry in the spirobicyclic system bearing three chiral centers is initially set via a highly diastereoselective zinc-mediated coupling of the allylic bromide 23 to the optically active ketopiperidine 3. The remaining benzylic asymmetric center is set by a diastereoselective hydroboration followed by cyclization to the spirobicyclic system.