40556-55-6Relevant academic research and scientific papers
Pharmaceutical compounds
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, (2008/06/13)
A compound of the formula in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group, said group being optionally substituted with 1 to 3 substituents selected from C1-4 alkyl, hydroxymethyl, C1-4 alkoxymethyl and amido, R3 is a naphthyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; and m is 0 or 1, provided that when m is 1 then n is 1; or a salt or ester thereof.
THE SYNTHESIS OF MANNICH BASES FROM KETONES AND ESTERS VIA ENAMINONES.
Schuda, Francis Paul,Ebner, Cynthia B.,Morgan, Tina M.
, p. 2567 - 2570 (2007/10/02)
The reactions of a series of activated methylene compounds with amide acetals to form high yields of enaminones is described.Further conversion to the Mannich bases via reduction with lithium aluminium hydride is also covered.
