40573-86-2

Usage

Uses

Used in Pharmaceutical Industry:
Dihydroartemisinin is used as an antimalarial agent for the treatment of malaria. It is commonly used in combination with other drugs to enhance its efficacy and reduce the risk of drug resistance.
Used in Antiparasitic Applications:
Dihydroartemisinin has shown potential in treating other parasitic diseases, making it a valuable compound in the development of new treatments for various parasitic infections.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, Dihydroartemisinin can be used in the development of new treatments for inflammatory conditions, potentially offering a novel therapeutic approach.
Used in Anticancer Applications:
Dihydroartemisinin has demonstrated anticancer activities, making it a promising candidate for further research and development in the field of oncology. Its potential use in cancer treatment could lead to the development of new therapies for various types of cancer.

Upstream product

• 14456-20-3 3β-acetoxy-5-androsten-17-one-17-ethyleneketal 
• 14456-20-3 3β-acetoxy-androst-5-ene-17,17-ethylenedioxy 
• 853-23-6 prasterone acetate 

Relevant academic research and scientific papers

Synthesis of 7β-hydroxy-epiandrosterone

The synthesis of 7β-hydroxy-epiandrosterone (6) possessing strong anti-inflammatory properties was achieved starting from 3β-acetoxy-17,17- (ethylenedioxy)-5-androsten (1). This approach involved as a main step an allylic oxidation of the C-7 followed by two reduction reactions of the double bond and of the carbonyl group. This stereoselective synthesis in 5 steps gave 7β-hydroxy-epiandrosterone in 63% overall yield.

Steroid derivative and preparation method thereof

The present invention relates to a steroid derivative and a preparation method thereof. The molecular structure of chlorambucil is improved on the basis of chlorambucil, the excellent anticancer curative effect of the core structure of chlorambucil is combined with the branched chain structure of a steroid parent nucleus with a good physiological activity effect to form a unique novel targeted anti-leukemia drug with a novel structure; when the steroid derivative is used for preparing an antitumor drug, the synthesis process and the preparation process are optimized, so the solvent consumptionis reduced, and the environment is protected; and the prepared drug reduces the clinical potential safety hazard.

METHODS FOR PREPARING 17-ALKYNYL-7-HYDROXY STEROIDS AND RELATED COMPOUNDS

The invention relates to processes for preparing 17-alkynyl-7-hydroxy- steroids, such as 17-Ethynyl-10R13S-dimethyl 2,3,4,7,8R,9S, 10,11,12,13,14S,15,16,17-hexadecahydro-1 H-cyclopenta[a]phenanthrene- 3R,7R,17S-triol (also referred to as 17α-ethynyl-androst-5-ene-3β,7β,17β-triol), that are essentially free of process impurities having binding activity at nuclear estrogen receptors.

Novel methods for the preparation of dhea derivatives

The invention relates to a method for the production of DHEA derivatives, such as 7-oxo-DHEA and 7-hydroxy-DHEA, from DHEA itself.

Methods for preparing 7alpha-hydroxy-dehydroepiandrosterone

The invention relates to new processes for preparing 7alpha-hydroxy-dehydroepiandrosterone of formula (1): 1

Synthetic approaches for the synthesis of a cytostatic steroidal B-D bilactam

A new synthetic procedure and a modification of the original method described in the literature for the synthesis of the steroidal B-D bilactam, 3β-hydroxy-7α,17α-diaza-B,D-dihomo-5-androsten-7,17-dione are reported. The key step in the modified method involved protection of the D-lactamic nitrogen atom of 3β-acetoxy-17α -aza-D-homo-5-androsten-17-one using a reagent of specific electrophilicity (due to the stereoelectronic properties of the cyclic amide), as Beckmann rearrangement of the B-steroidal ring was hindered, possibly via long range effects, by the presence of the unprotected D-lactamic moiety. Using the 3β-acetoxy-5-androsten-17-one as starting material, a new synthetic procedure was developed through ketalization of the 17-ketone and allylic oxidation to the 7-ketone, which was subsequently followed by Beckmann rearrangement of the B- and D-steroid rings. Both approaches resulted in 45 and 67% yields of the desired B,D-bilactam, respectively, in contrast to the 15% yield, which has been reported in the literature.

SYNTHESIS OF UNSATURATED CARBONYL COMPOUNDS VIA A CHROMIUM-MEDIATED ALLYLIC OXIDATION BY 70percent TERT.BUTYLHYDROPEROXIDE

Alkenes were converted into α,β-unsaturated carbonyl compounds using excess of tert.butylhydroperoxide and catalytic amounts of chromiumVI oxide at room temperature.Fair yields and conversions were obtained from Δ5-steroids while allylic oxidation of acyclic alkenes was less efficient.Epoxidation of the double bond, sometimes observed, remained a minor reaction pathway.