4058-78-0

Basic information

• Product Name: 4-amino-N-(2-methyl-2H-pyrazol-3-yl)-benzenesulfonamide
• Synonyms: 4-amino-N-(2-methyl-2H-pyrazol-3-yl)-benzenesulfonamide
• CAS NO: 4058-78-0
• Molecular Weight: 252.297
• Mol File: 4058-78-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-N-(2-methyl-2H-pyrazol-3-yl)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-(2-methyl-2H-pyrazol-3-yl)-benzenesulfonamide(4058-78-0)
• EPA Substance Registry System: 4-amino-N-(2-methyl-2H-pyrazol-3-yl)-benzenesulfonamide(4058-78-0)

Safety Data

• Hazardous Substances Data: 4058-78-0(Hazardous Substances Data)

Upstream product

• 1192-21-8 5-Amino-1-methylpyrazole 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Relevant articles and documents

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction

Identification of novel Hsp90 inhibitors to disrupt Hsp90-Cdc37 protein-protein interaction (PPI) could be an alternative strategy to achieve Hsp90 inhibition. In this paper, a series of small molecules targeting Hsp90-Cdc37 complex are addressed and characterized. The molecules' key characters are determined by utilizing a structure-based virtual screening workflow, derivatives synthesis, and biological evaluation. Structural optimization and structure–activity relationship (SAR) analysis were then carried out on the virtual hit of VS-8 with potent activity, which resulted in the discovery of compound 10 as a more potent regulator of Hsp90-Cdc37 interaction with a promising inhibitory effect (IC50?=?27?μM), a moderate binding capacity (KD?=?40?μM) and a preferable antiproliferative activity against several cancer lines including MCF-7, SKBR3 and A549?cell lines (IC50?=?26?μM, 15?μM and 38?μM respectively). All the data suggest that compound 10 exhibits moderate inhibitory effect on Hsp90-Cdc37 and could be regard as a first evidence of a non-natural compound targeting Hsp90-Cdc37 PPI.